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Local perfusion of mCPP into ventromedial hypothalamic nucleus, but not into lateral hypothalamic area and frontal cortex, inhibits food intake in rats

Local perfusion of mCPP into ventromedial hypothalamic nucleus, but not into lateral hypothalamic... These results indicate that the effects of 5-HT 1B or 5-HT 2C receptor activation on feeding behaviors depended on the brain regions, and that 5-HT 1B or 5-HT 2C receptors in VMH, but not in FC or in LH, play important roles in the regulation of food intake. The results also suggested that mCPP acts not only as a 5-HT 1B/2C agonist, but also as a 5-HT releaser or as a re-uptake inhibitor. Further studies using antagonists should be conducted. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychopharmacology Springer Journals

Local perfusion of mCPP into ventromedial hypothalamic nucleus, but not into lateral hypothalamic area and frontal cortex, inhibits food intake in rats

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References (55)

Publisher
Springer Journals
Copyright
Copyright © 2004 by Springer-Verlag
Subject
Medicine
ISSN
0033-3158
eISSN
1432-2072
DOI
10.1007/s00213-003-1735-0
pmid
14997269
Publisher site
See Article on Publisher Site

Abstract

These results indicate that the effects of 5-HT 1B or 5-HT 2C receptor activation on feeding behaviors depended on the brain regions, and that 5-HT 1B or 5-HT 2C receptors in VMH, but not in FC or in LH, play important roles in the regulation of food intake. The results also suggested that mCPP acts not only as a 5-HT 1B/2C agonist, but also as a 5-HT releaser or as a re-uptake inhibitor. Further studies using antagonists should be conducted.

Journal

PsychopharmacologySpringer Journals

Published: Jul 1, 2004

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