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Ion-Selective Electrodes for Determination of Some Sulfanilamide Drugs

Ion-Selective Electrodes for Determination of Some Sulfanilamide Drugs Pharmaceutical Chemistry Journal Vol. 34, No. 12, 2000 ION-SELECTIVE ELECTRODES FOR DETERMINATION OF SOME SULFANILAMIDE DRUGS 1 1 S. V. Kharitonov and I. P. Gorelov Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 34, No. 12, pp. 45 – 47, December, 2000. Original article submitted April 18, 2000. Most ion-selective electrodes (ISEs) developed so far for the chloroform fraction was removed in a separatory funnel, determination of drugs are based on the use of ion-exchange the solvent was driven off under vacuum (at 25°C), and the systems. If the drug involves compounds containing organic residue formed in the evaporator was used as the electrode anions, then most often quaternary ammonium salts are used active substance. Its composition was monitored by spectral for their conversion to an electrode-active substance [1 – 7]. methods. In particular, for determination of anions of the sulfanil- The starting solutions of the potassium salts of the sulfa- amide drugs norsulfazole, sulfadoxin, and sulfamethoxazole, nilamide drugs, which had been obtained by reaction of the the membranes include their cetyltriphenylphosphonium [8] corresponding drugs with KOH, were prepared using accu- and cetyltrioctylammonium [9] associates. But the electrodes rately weighed amounts in twice-distilled water; the more di- described have a narrow range http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pharmaceutical Chemistry Journal Springer Journals

Ion-Selective Electrodes for Determination of Some Sulfanilamide Drugs

Pharmaceutical Chemistry Journal , Volume 34 (12) – Oct 8, 2004

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References (5)

Publisher
Springer Journals
Copyright
Copyright © 2000 by Plenum Publishing Corporation
Subject
Pharmacy; Pharmacology/Toxicology; Organic Chemistry; Pharmacy
ISSN
0091-150X
eISSN
1573-9031
DOI
10.1023/A:1010464120998
Publisher site
See Article on Publisher Site

Abstract

Pharmaceutical Chemistry Journal Vol. 34, No. 12, 2000 ION-SELECTIVE ELECTRODES FOR DETERMINATION OF SOME SULFANILAMIDE DRUGS 1 1 S. V. Kharitonov and I. P. Gorelov Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 34, No. 12, pp. 45 – 47, December, 2000. Original article submitted April 18, 2000. Most ion-selective electrodes (ISEs) developed so far for the chloroform fraction was removed in a separatory funnel, determination of drugs are based on the use of ion-exchange the solvent was driven off under vacuum (at 25°C), and the systems. If the drug involves compounds containing organic residue formed in the evaporator was used as the electrode anions, then most often quaternary ammonium salts are used active substance. Its composition was monitored by spectral for their conversion to an electrode-active substance [1 – 7]. methods. In particular, for determination of anions of the sulfanil- The starting solutions of the potassium salts of the sulfa- amide drugs norsulfazole, sulfadoxin, and sulfamethoxazole, nilamide drugs, which had been obtained by reaction of the the membranes include their cetyltriphenylphosphonium [8] corresponding drugs with KOH, were prepared using accu- and cetyltrioctylammonium [9] associates. But the electrodes rately weighed amounts in twice-distilled water; the more di- described have a narrow range

Journal

Pharmaceutical Chemistry JournalSpringer Journals

Published: Oct 8, 2004

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