B. Dubois +33 4 37 28 23 91 dubois@cervi-lyon.inserm.fr A. Goubier G. Joubert D. Kaiserlian INSERM U404, Immunité et Vaccination IFR-128 Biosciences Lyon Gerland 21 avenue Tony Garnier 69365 Lyon, Cedex 07 France Abstract. Regulated mechanisms sustain the ability of the gut immune system to discriminate harmless food antigens (Ag) and commensal bacteria from pathogenic microorganisms, resulting in tolerance versus protective immunity, respectively. Antigens of the gut commensals are not simply ignored, but rather trigger an active immunosuppressive process, more commonly known as oral tolerance, which prevents the outcome of immunopathology. Both intrinsic properties of the gut microenvironment and cellular actors, as well as peripheral events induced by systemic dissemination of oral Ag, promote the induction of regulatory mechanisms that ensure maintenance of gut homeostasis. The aim of this review is to provide a synthetic update on the mechanisms of oral tolerance, with particular emphasis on the complex interplay between regulatory CD4 + T cells, dendritic cells and the gut microenvironment.
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Intestinal epithelial barrier and mucosal immunity
B., Dubois; A., Goubier; G., Joubert; D., Kaiserlian
Follow Cellular and Molecular Life Sciences
, Volume 62 (12)
Springer Journals – Jun 1, 2005
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