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Influence of short term verapamil treatment on glucose metabolism in patients with non-insulin dependent diabetes mellitus

Influence of short term verapamil treatment on glucose metabolism in patients with non-insulin... 228 41 41 5 5 M. Busch Sørensen H. Sjøstrand H. Sengeløv M. Tiefenthal Thrane J. Juul Holst J. Lyngsøe Medical Department C Bispebjerg Hospital Copenhagen Denmark Institute of Medical Physiology C University of Copenhagen, Panum Institute Copenhagen Denmark Summary The effect of a sustained-release verapamil preparation on glucose metabolism was investigated in 10 patients with non-insulin dependent diabetes mellitus. In a single blind cross-over study verapamil 240 mg b.d. for 1 week lowered fasting plasma glucose from a mean value of 11.6 mmol/l to 10.3 mmol·l −1 , and the fasting glucose appearance rate was decreased from 1.5 to 1.2 mmol·min −1 . The decrease in fasting plasma glucose and glucose appearance rate was not related to the steady state plasma concentration of verapamil, nor-verapamil and the metabolites D.617 and D.620. After oral glucose administration a tendency to lower plasma glucose values was found after verapamil administration. Plasma insulin, C-peptide, total and C-terminal glucagon were not significantly different in the placebo and the verapamil studies, neither in the fasting state nor after glucose. It is concluded that brief verapamil treatment decreases fasting plasma glucose and glucose turn-over in non-insulin dependent diabetics, possibly by inhibition of gluconeogenesis. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Clinical Pharmacology Springer Journals

Influence of short term verapamil treatment on glucose metabolism in patients with non-insulin dependent diabetes mellitus

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References (28)

Publisher
Springer Journals
Copyright
Copyright © 1991 by Springer-Verlag
Subject
Biomedicine; Pharmacology/Toxicology
ISSN
0031-6970
eISSN
1432-1041
DOI
10.1007/BF00626359
Publisher site
See Article on Publisher Site

Abstract

228 41 41 5 5 M. Busch Sørensen H. Sjøstrand H. Sengeløv M. Tiefenthal Thrane J. Juul Holst J. Lyngsøe Medical Department C Bispebjerg Hospital Copenhagen Denmark Institute of Medical Physiology C University of Copenhagen, Panum Institute Copenhagen Denmark Summary The effect of a sustained-release verapamil preparation on glucose metabolism was investigated in 10 patients with non-insulin dependent diabetes mellitus. In a single blind cross-over study verapamil 240 mg b.d. for 1 week lowered fasting plasma glucose from a mean value of 11.6 mmol/l to 10.3 mmol·l −1 , and the fasting glucose appearance rate was decreased from 1.5 to 1.2 mmol·min −1 . The decrease in fasting plasma glucose and glucose appearance rate was not related to the steady state plasma concentration of verapamil, nor-verapamil and the metabolites D.617 and D.620. After oral glucose administration a tendency to lower plasma glucose values was found after verapamil administration. Plasma insulin, C-peptide, total and C-terminal glucagon were not significantly different in the placebo and the verapamil studies, neither in the fasting state nor after glucose. It is concluded that brief verapamil treatment decreases fasting plasma glucose and glucose turn-over in non-insulin dependent diabetics, possibly by inhibition of gluconeogenesis.

Journal

European Journal of Clinical Pharmacology – Springer Journals

Published: Sep 1, 1991

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