Access the full text.
Sign up today, get DeepDyve free for 14 days.
H. Kuzuya, P. Blix, D. Horwitz, D. Steiner, A. Rubenstein (1977)
Determination of Free and Total Insulin and C-Peptide in Insulin-treated DiabeticsDiabetes, 26
P. Sejrsen (1971)
Measurement of cutaneous blood flow by freely diffusible radioactive isotopes. Methodological studies on the washout of krypton-85 and xenon-133 from the cutaneous tissue in man.Danish medical bulletin, 18
P. Hildebrandt, K. Birch, L. Sestoft, A. Vølund (2009)
Dose-dependent subcutaneous absorption of porcine, bovine and human NPH insulins.Acta medica Scandinavica, 215 1
O. Larsen, N. Lassen, F. Quaade (1966)
Blood flow through human adipose tissue determined with radioactive xenon.Acta physiologica Scandinavica, 66 3
T. Deckert, B. Hansen, T. Lauritzen, J. Christiansen (1981)
Subcutaneous degradation of insulinDiabetologia, 21
(1983)
Non - linear relationship between subcutaneous blood flow and insulin absorption
R. DeFronzo, R. Hendler, D. Simonson (1982)
Insulin Resistance is a Prominent Feature of Insulin-dependent DiabetesDiabetes, 31
M. Berger, H. Cüppers, P. Halban, R. Offord (1980)
The Effect of Aprotinin on the Absorption of Subcutaneously Injected Regular Insulin in Normal SubjectsDiabetes, 29
Per Hildebrandt, L. Sestoft, S. Nielsen (1983)
The Absorption of Subcutaneously Injected Short-Acting Soluble Insulin: Influence of Injection Technique and ConcentrationDiabetes Care, 6
S. Kety (1949)
Measurement of regional circulation by the local clearance of radioactive sodium.American heart journal, 38 3
(1984)
Aprotinin administered together with insulin has no effect on blood glucose levels in type 1 diabetics
G. Williams, J. Pickup, S. Bowcock, E. Cooke, H. Keen (1983)
Subcutaneous aprotinin causes local hyperaemiaDiabetologia, 24
T. Lauritzen, C. Binder, Faber Ok (1980)
IMPORTANCE OF INSULIN ABSORPTION, SUBCUTANEOUS BLOOD FLOW, AND RESIDUAL BETA‐CELL FUNCTION IN INSULIN THERAPYActa Pædiatrica, 69
K. Kølendorf, J. Bojsen, S. Nielsen (1979)
Adipose tissue blood flow and insulin disappearance from subcutaneous tissueClinical Pharmacology & Therapeutics, 25
L. Heding (1972)
Determination of total serum insulin (IRI) in insulin-treated diabetic patientsDiabetologia, 8
P. Hildebrandt, K. Birch, L. Sestoft, S. Nielsen (1985)
Orthostatic changes in subcutaneous blood flow and insulin absorption.Diabetes research, 2 4
G. Freidenberg, N. White, S. Cataland, T. O'dorisio, J. Sotos, J. Santiago (1981)
Diabetes responsive to intravenous but not subcutaneous insulin: effectiveness of aprotinin.The New England journal of medicine, 305 7
Mitchel Berger, Cüppers Hj, H. Hegner, V. Jörgens, P. Berchtold (1982)
Absorption Kinetics and Biologic Effects of Subcutaneously Injected Insulin PreparationsDiabetes Care, 5
125 28 28 9 9 B. Linde R. Gunnarsson Departments of Clinical Physiology and Medicine Huddinge Hospital Huddinge Sweden Summary Ten normal-weight Type 1 (insulin-dependent) diabetic patients (12 h postprandial) with normal insulin requirement were given 125 I-labelled soluble insulin (10 U) in the thigh together with aprotinin (10000 KIU) or its diluent on two consecutive mornings. Disappearance of 125 I-radioactivity was followed continuously for 3 h by external detection and plasma free insulin measured by radioimmunoassay. Subcutaneous blood flow following aprotinin or diluent was studied concomitantly in the contralateral thigh by external monitoring of locally injected 133 Xenon. Plasma free insulin increased significantly faster ( p <0.05) and the insulin area under the curve was significantly ( p <0.05) greater during the first hour after injection of insulin with aprotinin. Subcutaneous blood flow (rate constants for 133 Xenon) was significantly higher with aprotinin ( p <0.05), the highest flow occurring early after injection. In conclusion, subcutaneously injected soluble insulin is more rapidly absorbed by addition of aprotinin to the insulin solution in Type 1 diabetes. Blood flow increase at the injection site may explain part of this effect.
Diabetologia – Springer Journals
Published: Sep 1, 1985
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.