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Influence of aprotinin on insulin absorption and subcutaneous blood flow in Type 1 (insulin-dependent) diabetes

Influence of aprotinin on insulin absorption and subcutaneous blood flow in Type 1... 125 28 28 9 9 B. Linde R. Gunnarsson Departments of Clinical Physiology and Medicine Huddinge Hospital Huddinge Sweden Summary Ten normal-weight Type 1 (insulin-dependent) diabetic patients (12 h postprandial) with normal insulin requirement were given 125 I-labelled soluble insulin (10 U) in the thigh together with aprotinin (10000 KIU) or its diluent on two consecutive mornings. Disappearance of 125 I-radioactivity was followed continuously for 3 h by external detection and plasma free insulin measured by radioimmunoassay. Subcutaneous blood flow following aprotinin or diluent was studied concomitantly in the contralateral thigh by external monitoring of locally injected 133 Xenon. Plasma free insulin increased significantly faster ( p <0.05) and the insulin area under the curve was significantly ( p <0.05) greater during the first hour after injection of insulin with aprotinin. Subcutaneous blood flow (rate constants for 133 Xenon) was significantly higher with aprotinin ( p <0.05), the highest flow occurring early after injection. In conclusion, subcutaneously injected soluble insulin is more rapidly absorbed by addition of aprotinin to the insulin solution in Type 1 diabetes. Blood flow increase at the injection site may explain part of this effect. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Diabetologia Springer Journals

Influence of aprotinin on insulin absorption and subcutaneous blood flow in Type 1 (insulin-dependent) diabetes

Diabetologia , Volume 28 (9) – Sep 1, 1985

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References (18)

Publisher
Springer Journals
Copyright
Copyright © 1985 by Springer-Verlag
Subject
Medicine & Public Health; Internal Medicine; Metabolic Diseases; Human Physiology
ISSN
0012-186X
eISSN
1432-0428
DOI
10.1007/BF00291968
Publisher site
See Article on Publisher Site

Abstract

125 28 28 9 9 B. Linde R. Gunnarsson Departments of Clinical Physiology and Medicine Huddinge Hospital Huddinge Sweden Summary Ten normal-weight Type 1 (insulin-dependent) diabetic patients (12 h postprandial) with normal insulin requirement were given 125 I-labelled soluble insulin (10 U) in the thigh together with aprotinin (10000 KIU) or its diluent on two consecutive mornings. Disappearance of 125 I-radioactivity was followed continuously for 3 h by external detection and plasma free insulin measured by radioimmunoassay. Subcutaneous blood flow following aprotinin or diluent was studied concomitantly in the contralateral thigh by external monitoring of locally injected 133 Xenon. Plasma free insulin increased significantly faster ( p <0.05) and the insulin area under the curve was significantly ( p <0.05) greater during the first hour after injection of insulin with aprotinin. Subcutaneous blood flow (rate constants for 133 Xenon) was significantly higher with aprotinin ( p <0.05), the highest flow occurring early after injection. In conclusion, subcutaneously injected soluble insulin is more rapidly absorbed by addition of aprotinin to the insulin solution in Type 1 diabetes. Blood flow increase at the injection site may explain part of this effect.

Journal

DiabetologiaSpringer Journals

Published: Sep 1, 1985

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