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Hypomagnesaemia in childhood IDDM and risk of nephropathy

Hypomagnesaemia in childhood IDDM and risk of nephropathy Diabetologia (1995) 38:629-634 Diabetologia 9 Springer-Verlag 1995 Letters to the editor Dear Sir, In their recent letter Pickup and colleagues [1] mentioned that they could not demonstrate any gross deviation of magnesaemia from normal levels in proteinuric diabetic patients. Although there are some published studies on the role of hypomagnesaemia in the development of certain complications of non-insulin-dependent diabetes mellitus (NIDDM) [2, 31 and on Na + -dependent inositol transport in vitro [4] its effect in insulin-dependent diabetes (IDDM) has not been documented. Therefore, we investigated the relationship between magnesaemia and albuminuria in children with IDDM. We studied 80 children and adolescents with I D D M of differing durations (Table 1). Two serum samples obtained at different times were analysed for magnesium using calmagite kits. Twentyfour-hour urine collections were made at least three times at monthly intervals. Albumin was measured using double antibody radioimmunoassay. The mean values for two serum magnesium levels and three urinary albumin excretion rates were calculated. Hypomagnesaemia was found in 24 patients according to the reference criteria of our laboratory (< 0.70 mmol/1). Microalbuminuria was found in 30 patients (38%) defined as urinary albumin excretion greater than 20 rag/rain; 11 of the patients http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Diabetologia Springer Journals

Hypomagnesaemia in childhood IDDM and risk of nephropathy

Diabetologia , Volume 38 (5) – May 1, 1995

Hypomagnesaemia in childhood IDDM and risk of nephropathy

Abstract

Diabetologia (1995) 38:629-634 Diabetologia 9 Springer-Verlag 1995 Letters to the editor Dear Sir, In their recent letter Pickup and colleagues [1] mentioned that they could not demonstrate any gross deviation of magnesaemia from normal levels in proteinuric diabetic patients. Although there are some published studies on the role of hypomagnesaemia in the development of certain complications of non-insulin-dependent diabetes mellitus (NIDDM) [2, 31 and on Na + -dependent inositol transport...
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References (4)

Publisher
Springer Journals
Copyright
Copyright © 1995 by Springer-Verlag
Subject
Medicine & Public Health; Human Physiology; Internal Medicine; Metabolic Diseases
ISSN
0012-186X
eISSN
1432-0428
DOI
10.1007/BF00400735
Publisher site
See Article on Publisher Site

Abstract

Diabetologia (1995) 38:629-634 Diabetologia 9 Springer-Verlag 1995 Letters to the editor Dear Sir, In their recent letter Pickup and colleagues [1] mentioned that they could not demonstrate any gross deviation of magnesaemia from normal levels in proteinuric diabetic patients. Although there are some published studies on the role of hypomagnesaemia in the development of certain complications of non-insulin-dependent diabetes mellitus (NIDDM) [2, 31 and on Na + -dependent inositol transport in vitro [4] its effect in insulin-dependent diabetes (IDDM) has not been documented. Therefore, we investigated the relationship between magnesaemia and albuminuria in children with IDDM. We studied 80 children and adolescents with I D D M of differing durations (Table 1). Two serum samples obtained at different times were analysed for magnesium using calmagite kits. Twentyfour-hour urine collections were made at least three times at monthly intervals. Albumin was measured using double antibody radioimmunoassay. The mean values for two serum magnesium levels and three urinary albumin excretion rates were calculated. Hypomagnesaemia was found in 24 patients according to the reference criteria of our laboratory (< 0.70 mmol/1). Microalbuminuria was found in 30 patients (38%) defined as urinary albumin excretion greater than 20 rag/rain; 11 of the patients

Journal

DiabetologiaSpringer Journals

Published: May 1, 1995

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