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Hormonal changes induced by a partial opiate antagonist, nalorphine. Evaluation of PRL, GH, TSH, LH, FSH and cortisol secretion

Hormonal changes induced by a partial opiate antagonist, nalorphine. Evaluation of PRL, GH, TSH,... 228 21 21 1 1 E. Rolandi G. Magnani A. Sannia T. Barreca Istituto Scientifico di Medicina Interna, Cattedra di Patologia Medica R Università degli Studi di Genova Genova Italy Summary The effects of nalorphine 5 mg i. m., a partial opiate antagonist, on circulating levels of PRL, GH, TSH, LH, FSH and cortisol were studied in six healthy men. Nalorphine produced a prompt and sharp increase in serum PRL and a small, delayed rise in serum GH. Serum LH and cortisol decreased after drug administration and no change in serum FSH and TSH was observed. These findings are discussed and a possible site of action of nalorphine is suggested. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Clinical Pharmacology Springer Journals

Hormonal changes induced by a partial opiate antagonist, nalorphine. Evaluation of PRL, GH, TSH, LH, FSH and cortisol secretion

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References (20)

Publisher
Springer Journals
Copyright
Copyright © 1981 by Springer-Verlag
Subject
Biomedicine; Pharmacology/Toxicology
ISSN
0031-6970
eISSN
1432-1041
DOI
10.1007/BF00609583
Publisher site
See Article on Publisher Site

Abstract

228 21 21 1 1 E. Rolandi G. Magnani A. Sannia T. Barreca Istituto Scientifico di Medicina Interna, Cattedra di Patologia Medica R Università degli Studi di Genova Genova Italy Summary The effects of nalorphine 5 mg i. m., a partial opiate antagonist, on circulating levels of PRL, GH, TSH, LH, FSH and cortisol were studied in six healthy men. Nalorphine produced a prompt and sharp increase in serum PRL and a small, delayed rise in serum GH. Serum LH and cortisol decreased after drug administration and no change in serum FSH and TSH was observed. These findings are discussed and a possible site of action of nalorphine is suggested.

Journal

European Journal of Clinical PharmacologySpringer Journals

Published: Jan 1, 1981

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