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Hepatocarcinoma-29, a Metastasizing Transplantable Mouse Tumor Inducing Cachexia

Hepatocarcinoma-29, a Metastasizing Transplantable Mouse Tumor Inducing Cachexia Here we describe an experimental tumor, hepatocarcinoma-29: transplantable strain of this tumor is maintained in an ascitic form in СВА/LacYIcgn mice in Institute of Cytology and Genetics of SD of RAS. After inoculation into the thigh muscles, the tumor induces anorexia, progressing loss of fat and muscle tissues, and physiological changes specific for cachexia: leukocytosis, hypoglycemia, and hypercorticism. The tumor metastasizes to all vital viscera and leads to animal death from renal failure. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Bulletin of Experimental Biology and Medicine Springer Journals

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References (6)

Publisher
Springer Journals
Copyright
Copyright © 2009 by Springer Science+Business Media, Inc.
Subject
Biomedicine; Laboratory Medicine ; Pathology ; Cell Biology; Internal Medicine ; Biomedicine general
ISSN
0007-4888
eISSN
1573-8221
DOI
10.1007/s10517-010-0848-9
Publisher site
See Article on Publisher Site

Abstract

Here we describe an experimental tumor, hepatocarcinoma-29: transplantable strain of this tumor is maintained in an ascitic form in СВА/LacYIcgn mice in Institute of Cytology and Genetics of SD of RAS. After inoculation into the thigh muscles, the tumor induces anorexia, progressing loss of fat and muscle tissues, and physiological changes specific for cachexia: leukocytosis, hypoglycemia, and hypercorticism. The tumor metastasizes to all vital viscera and leads to animal death from renal failure.

Journal

Bulletin of Experimental Biology and MedicineSpringer Journals

Published: May 25, 2010

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