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Gas chromatographic assessment of the reproducibility of phenazone plasma half-life in young healthy volunteers

Gas chromatographic assessment of the reproducibility of phenazone plasma half-life in young... 228 7 7 5 5 S. Lindgren P. Collste B. Norlander F. Sjöqvist Department of Clinical Pharmacology University of Linköping S-581 85 Linköping Sweden Summary Intra-individual variability in the plasma half-life of phenazone has been studied in 16 healthy, young volunteers. Phenazone was analysed by a simple gas chromatographic method, which is specific in relation to known metabolites; 4′-methylphenazone was employed as the internal standard. Phenazone was given on two occasions, two or three months apart, in oral doses of 10 mg/kg. The plasma half-life determined from five time points was 10.9±1.5 h and 11.2±1.3 h respectively, on the two occasions. The mean intra-individual variability (0.86 h) was close to the methodological error of 4%. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Clinical Pharmacology Springer Journals

Gas chromatographic assessment of the reproducibility of phenazone plasma half-life in young healthy volunteers

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References (21)

Publisher
Springer Journals
Copyright
Copyright © 1974 by Springer-Verlag
Subject
Biomedicine; Pharmacology/Toxicology
ISSN
0031-6970
eISSN
1432-1041
DOI
10.1007/BF00558211
Publisher site
See Article on Publisher Site

Abstract

228 7 7 5 5 S. Lindgren P. Collste B. Norlander F. Sjöqvist Department of Clinical Pharmacology University of Linköping S-581 85 Linköping Sweden Summary Intra-individual variability in the plasma half-life of phenazone has been studied in 16 healthy, young volunteers. Phenazone was analysed by a simple gas chromatographic method, which is specific in relation to known metabolites; 4′-methylphenazone was employed as the internal standard. Phenazone was given on two occasions, two or three months apart, in oral doses of 10 mg/kg. The plasma half-life determined from five time points was 10.9±1.5 h and 11.2±1.3 h respectively, on the two occasions. The mean intra-individual variability (0.86 h) was close to the methodological error of 4%.

Journal

European Journal of Clinical Pharmacology – Springer Journals

Published: Sep 1, 1974

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