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Further developments in the modelling of a sequential chromatographic refiner unit

Further developments in the modelling of a sequential chromatographic refiner unit A classical plate-type model developed to simulate the separation of binary mixtures by sequential semicontinuous chromatography is modified by the inclusion of a separate expression to account for the effects of solute concentration on the feed plate. The improved model is tested on three systems of different separation difficulty, for which experimental data are available. Comparison of experimental and simulated separations is achieved by consideration of the solute concentration profiles. In determining the success of the simulation, particular note is made of profile shape, feed point location and concentration levels. Best agreement between experimental and simulated profiles is shown to exist for high separation factor systems at low flowrates and low temperatures. Relatively poor agreement for difficult systems at higher flowrates is attributed to phase changes, column temperature effects and the influence of the anti-Langmuir shape of the absorption isotherm. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Chromatographia Springer Journals

Further developments in the modelling of a sequential chromatographic refiner unit

Barker, P.; Howari, M.; Irlam, G.
Chromatographia , Volume 14 (4) – Apr 1, 1981
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References (3)

Publisher
Springer Journals
Copyright
Copyright © 1981 by Friedr. Vieweg & Sohn Verlagsgesellschaft mbH
Subject
Chemistry; Analytical Chemistry; Organic Chemistry; Biochemistry, general; Plant Sciences; Pharmacy; Measurement Science, Instrumentation
ISSN
0009-5893
eISSN
1612-1112
DOI
10.1007/BF02260151
Publisher site
See Article on Publisher Site

Abstract

A classical plate-type model developed to simulate the separation of binary mixtures by sequential semicontinuous chromatography is modified by the inclusion of a separate expression to account for the effects of solute concentration on the feed plate. The improved model is tested on three systems of different separation difficulty, for which experimental data are available. Comparison of experimental and simulated separations is achieved by consideration of the solute concentration profiles. In determining the success of the simulation, particular note is made of profile shape, feed point location and concentration levels. Best agreement between experimental and simulated profiles is shown to exist for high separation factor systems at low flowrates and low temperatures. Relatively poor agreement for difficult systems at higher flowrates is attributed to phase changes, column temperature effects and the influence of the anti-Langmuir shape of the absorption isotherm.

Journal

Chromatographia – Springer Journals

Published: Apr 1, 1981

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