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Functional Activity of P-Glycoprotein in Lymphocytes of Patients with Lymphoproliferative Diseases

Functional Activity of P-Glycoprotein in Lymphocytes of Patients with Lymphoproliferative Diseases Functional activity of P-glycoprotein in lymphocytes of patients with lymphoproliferative diseases was studied using rhodamine 123. Functional activity of P-glycoprotein in patients receiving a course of chemotherapy was lower than in controls. P-glycoprotein activity was higher in patients receiving more aggressive therapy. Initially activity of P-glycoprotein was higher in patients who did not respond to chemotherapy in comparison with those whose clinical status improved after a course of chemotherapy. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Bulletin of Experimental Biology and Medicine Springer Journals

Functional Activity of P-Glycoprotein in Lymphocytes of Patients with Lymphoproliferative Diseases

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References (5)

Publisher
Springer Journals
Copyright
Copyright © 2003 by Plenum Publishing Corporation
Subject
Biomedicine; Biomedicine, general; Internal Medicine; Cell Biology; Pathology; Laboratory Medicine
ISSN
0007-4888
eISSN
1573-8221
DOI
10.1023/B:BEBM.0000017100.62385.a0
Publisher site
See Article on Publisher Site

Abstract

Functional activity of P-glycoprotein in lymphocytes of patients with lymphoproliferative diseases was studied using rhodamine 123. Functional activity of P-glycoprotein in patients receiving a course of chemotherapy was lower than in controls. P-glycoprotein activity was higher in patients receiving more aggressive therapy. Initially activity of P-glycoprotein was higher in patients who did not respond to chemotherapy in comparison with those whose clinical status improved after a course of chemotherapy.

Journal

Bulletin of Experimental Biology and MedicineSpringer Journals

Published: Oct 5, 2004

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