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Excretion of phenotropyl from the rat organism

Excretion of phenotropyl from the rat organism Pharmaceutical Chemistry Journal Vol. 38, No. 11, 2004 EXCRETION OF PHENOTROPYL FROM THE RAT ORGANISM 1 1 1 M. I. Antonova, A. A. Prokopov, V. I. Akhapkina, and A. S. Berlyand Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 38, No. 11, pp.6–7, November, 2004. Original article submitted February 16, 2004. Phenotropyl, or 1-(4-phenyl-2-pyrrolidone)acetamide, is The quantitative determination of phenotropyl in the urine a new original domestic drug possessing high nootropic ac- samples was performed using gas chromatography as de- tivity [1]. Previously, the pharmacokinetics of phenotropyl scribed in [3]. upon administration by various methods in rats was experi- mentally studied by monitoring the drug concentration dy- RESULTS AND DISCUSSION namics in the blood plasma [2]. Another inseparable part of the characterization of drug pharmacokinetics is investiga- The results of investigation of the kinetics of phenotropyl tion of the excretion of parent compounds and their metabo- excretion with urine from the rat organism are presented in lites from the organism. Table 1. As can be seen from these data, about 7.74 mg of the The aim of this study was to monitor the excretion of drug (about 38.7 % of the administered dose) is excreted phenotropyl upon single peroral administration in rats. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pharmaceutical Chemistry Journal Springer Journals

Excretion of phenotropyl from the rat organism

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References (1)

Publisher
Springer Journals
Copyright
Copyright © 2004 by Springer Science+Business Media, Inc.
Subject
Pharmacy; Pharmacology/Toxicology; Organic Chemistry; Pharmacy
ISSN
0091-150X
eISSN
1573-9031
DOI
10.1007/s11094-005-0035-x
Publisher site
See Article on Publisher Site

Abstract

Pharmaceutical Chemistry Journal Vol. 38, No. 11, 2004 EXCRETION OF PHENOTROPYL FROM THE RAT ORGANISM 1 1 1 M. I. Antonova, A. A. Prokopov, V. I. Akhapkina, and A. S. Berlyand Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 38, No. 11, pp.6–7, November, 2004. Original article submitted February 16, 2004. Phenotropyl, or 1-(4-phenyl-2-pyrrolidone)acetamide, is The quantitative determination of phenotropyl in the urine a new original domestic drug possessing high nootropic ac- samples was performed using gas chromatography as de- tivity [1]. Previously, the pharmacokinetics of phenotropyl scribed in [3]. upon administration by various methods in rats was experi- mentally studied by monitoring the drug concentration dy- RESULTS AND DISCUSSION namics in the blood plasma [2]. Another inseparable part of the characterization of drug pharmacokinetics is investiga- The results of investigation of the kinetics of phenotropyl tion of the excretion of parent compounds and their metabo- excretion with urine from the rat organism are presented in lites from the organism. Table 1. As can be seen from these data, about 7.74 mg of the The aim of this study was to monitor the excretion of drug (about 38.7 % of the administered dose) is excreted phenotropyl upon single peroral administration in rats.

Journal

Pharmaceutical Chemistry Journal – Springer Journals

Published: Apr 7, 2005

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