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- Publisher
- Springer Journals
- Copyright
- Copyright © 2007 by Birkhaueser
- Subject
- Life Sciences; Biochemistry, general; Life Sciences, general ; Biomedicine general; Cell Biology
- ISSN
- 1420-682X
- eISSN
- 1420-9071
- DOI
- 10.1007/s00018-007-7383-5
- pmid
- 18038217
- Publisher site
- See Article on Publisher Site
Abstract
In homeostasis, cellular processes are in a dynamic equilibrium. Perturbation of homeostasis causes stress. In this review I summarize how perturbation of three major functions of the endoplasmic reticulum (ER) in eukaryotic cells–protein folding, lipid and sterol biosynthesis, and storing intracellular Ca2+ – causes ER stress and activates signaling pathways collectively termed the unfolded protein response (UPR). I discuss how the UPR reestablishes homeostasis, and summarize our current understanding of how the transition from protective to apoptotic UPR signaling is controlled, and how the UPR induces inflammatory signaling.
Journal
Cellular and Molecular Life Sciences – Springer Journals
Published: Nov 26, 2007