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Journals European Journal of Clinical Pharmacology Volume 67 Issue 7

SLCO1B1*1B/*1B genotype is associated with reduced pharmacokinetic exposure after a single dose oral administration of 2 mg repaglinide, including decreased AUC 0-∞ and increased clearance of repaglinide. Moreover, this polymorphism of SLCO1B1 has significant influence on the pharmacokinetics of repaglinide, but no effects on its pharmacodynamics.

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Effects of SLCO1B1 polymorphisms on the pharmacokinetics and pharmacodynamics of repaglinide in healthy Chinese volunteers

More Info
  • Publisher Springer-Verlag
  • Copyright Copyright © 2011 by Springer-Verlag
  • Subject Biomedicine; Pharmacology/Toxicology
  • ISSN 0031-6970
  • eISSN 1432-1041
  • D.O.I. 10.1007/s00228-011-0994-7
  • Publisher site Get PDF  

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