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Effects of monosodium glutamate administration in the neonatal period on the diabetic syndrome in KK mice

Effects of monosodium glutamate administration in the neonatal period on the diabetic syndrome in... 125 12 12 6 6 D. P. Cameron T. K. -Y. Poon G. C. Smith Medical Research Centre Prince Henry's Hospital Melbourne Department of Anatomy Monash University Clayton Australia Summary Administration of monosodium glutamate (MSG) to KK mice during the neonatal period resulted in a syndrome of obesity, stunting and hypogonadism. In some animals the genetic predisposition to diabetes was unmasked with the development of marked hyperglycaemia and or hyperinsulinaemia. Food intake was not increased compared to controls. The elevated plasma glucose and insulin in fed MSG treated mice fell rapidly with food deprivation. Glucose disposal was comparable in MSG treated and control mice after IP glucose, but after oral glucose MSG treated mice showed impaired glucose tolerance. Insulin secretion was defective in MSG treated mice after IP but not after oral glucose. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Diabetologia Springer Journals

Effects of monosodium glutamate administration in the neonatal period on the diabetic syndrome in KK mice

Cameron, D.; Poon, T.; Smith, G.
Diabetologia , Volume 12 (6) – Dec 1, 1976
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References (32)

Publisher
Springer Journals
Copyright
Copyright © 1976 by Springer-Verlag
Subject
Medicine & Public Health; Human Physiology; Internal Medicine; Metabolic Diseases
ISSN
0012-186X
eISSN
1432-0428
DOI
10.1007/BF01220641
Publisher site
See Article on Publisher Site

Abstract

125 12 12 6 6 D. P. Cameron T. K. -Y. Poon G. C. Smith Medical Research Centre Prince Henry's Hospital Melbourne Department of Anatomy Monash University Clayton Australia Summary Administration of monosodium glutamate (MSG) to KK mice during the neonatal period resulted in a syndrome of obesity, stunting and hypogonadism. In some animals the genetic predisposition to diabetes was unmasked with the development of marked hyperglycaemia and or hyperinsulinaemia. Food intake was not increased compared to controls. The elevated plasma glucose and insulin in fed MSG treated mice fell rapidly with food deprivation. Glucose disposal was comparable in MSG treated and control mice after IP glucose, but after oral glucose MSG treated mice showed impaired glucose tolerance. Insulin secretion was defective in MSG treated mice after IP but not after oral glucose.

Journal

Diabetologia – Springer Journals

Published: Dec 1, 1976

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