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Effect of two antacids on the bioavailability of paracetamol

Effect of two antacids on the bioavailability of paracetamol 228 29 29 2 2 H. Albin F. Demotes-Mainard G. Vinçon A. Bedjaoui B. Begaud Department of Clinical Pharmacology Hôpital Pellegrin Bordeaux France Summary The effect of two antacids on the bioavailability of paracetamol has been investigated in 12 young healthy volunteers. Following a random cross over design, each subject swallowed, on three separate occasions, one weak apart, 500 mg paracetamol alone, or together with two different aluminium hydroxide, magnesium hydroxide preparations (Dimalan and Maalox). Plasma paracetamol levels were measured by HPLC. The bioavailability of paracetamol was not altered by either antacid, but they both delayed the time to peak plasma concentration (0.85 h; 1.43 h; 1.25 h, without antacid, with Dimalan and with Maalox respectively). The peak plasma concentration was not affected by concurrent antacid administration. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Clinical Pharmacology Springer Journals

Effect of two antacids on the bioavailability of paracetamol

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References (26)

Publisher
Springer Journals
Copyright
Copyright © 1985 by Springer-Verlag
Subject
Biomedicine; Pharmacology/Toxicology
ISSN
0031-6970
eISSN
1432-1041
DOI
10.1007/BF00547432
Publisher site
See Article on Publisher Site

Abstract

228 29 29 2 2 H. Albin F. Demotes-Mainard G. Vinçon A. Bedjaoui B. Begaud Department of Clinical Pharmacology Hôpital Pellegrin Bordeaux France Summary The effect of two antacids on the bioavailability of paracetamol has been investigated in 12 young healthy volunteers. Following a random cross over design, each subject swallowed, on three separate occasions, one weak apart, 500 mg paracetamol alone, or together with two different aluminium hydroxide, magnesium hydroxide preparations (Dimalan and Maalox). Plasma paracetamol levels were measured by HPLC. The bioavailability of paracetamol was not altered by either antacid, but they both delayed the time to peak plasma concentration (0.85 h; 1.43 h; 1.25 h, without antacid, with Dimalan and with Maalox respectively). The peak plasma concentration was not affected by concurrent antacid administration.

Journal

European Journal of Clinical PharmacologySpringer Journals

Published: Mar 1, 1985

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