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R. Gibbins, H. Kalant, A. Blanc (1968)
A technique for accurate measurement of moderate degrees of alcohol intoxication in small animals.The Journal of pharmacology and experimental therapeutics, 159 1
A. Leblanc, H. Kalant, R. Gibbins, N. Berman (1969)
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(1974)
The effect ofp-CPA and lesions of the dorsal raphe nucleus on habituation of the flexor withdrawal
D. Frankel, J. Khanna, A. Leblanc, H. Kalant (1975)
Effect of p-chlorophenylalanine on the acquisition of tolerance to ethanol and pentobarbitalPsychopharmacologia, 44
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The effects of p-chlorophenylalanine, a serotonin depletor, on avoidance acquisition, pain sensitivity and related behavior in the ratPsychopharmacologia, 10
D. Frankel, J. Khanna, H. Kalant, A. Leblanc (1974)
Effect of acute and chronic ethanol administration on serotonin turnover in rat brainPsychopharmacologia, 37
H. Tilson, R. Rech (1974)
The effects of p-chlorophenylalanine on morphine analgesia, tolerance and dependence development in two strains of ratsPsychopharmacologia, 35
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The effect of p-CPA and lesions of the dorsal raphe nucleus on habituation of the flexor withdrawal reflex.Brain research, 77 3
213 57 57 3 3 David Frankel Jatinder M. Khanna Harold Kalant A. Eugene LeBlanc Department of Pharmacology University of Toronto, and Addiction Research Foundation of Ontario M5S 1A8 Toronto Canada Abstract Daily administration of ethanol in a liquid diet or by intubation were both effective in producing tolerance to the hypothermic effects of ethanol. When p -chlorophenylalanine ( p -CPA) was administered in a dose previously demonstrated to maintain extensive brain serotonin (5-HT) depletion, the temperature-lowering effects of ethanol were less pronounced than in corresponding controls. The analysis of the effect of p -CPA on tolerance development took into account both initial body temperature and the degree of hypothermia. This study extends our findings with respect to the inhibitory effect of p -CPA on the development of tolerance to the motor-impairing effects of ethanol, and suggests that 5-HT may have a role in tolerance development to ethanol.
Psychopharmacology – Springer Journals
Published: Jan 1, 1978
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