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Effect of p -chlorophenylalanine on the acquisition of tolerance to the hypothermic effects of ethanol

Effect of p -chlorophenylalanine on the acquisition of tolerance to the hypothermic effects of... 213 57 57 3 3 David Frankel Jatinder M. Khanna Harold Kalant A. Eugene LeBlanc Department of Pharmacology University of Toronto, and Addiction Research Foundation of Ontario M5S 1A8 Toronto Canada Abstract Daily administration of ethanol in a liquid diet or by intubation were both effective in producing tolerance to the hypothermic effects of ethanol. When p -chlorophenylalanine ( p -CPA) was administered in a dose previously demonstrated to maintain extensive brain serotonin (5-HT) depletion, the temperature-lowering effects of ethanol were less pronounced than in corresponding controls. The analysis of the effect of p -CPA on tolerance development took into account both initial body temperature and the degree of hypothermia. This study extends our findings with respect to the inhibitory effect of p -CPA on the development of tolerance to the motor-impairing effects of ethanol, and suggests that 5-HT may have a role in tolerance development to ethanol. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychopharmacology Springer Journals

Effect of p -chlorophenylalanine on the acquisition of tolerance to the hypothermic effects of ethanol

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References (14)

Publisher
Springer Journals
Copyright
Copyright © 1978 by Springer-Verlag
Subject
Biomedicine; Pharmacology/Toxicology; Psychiatry
ISSN
0033-3158
eISSN
1432-2072
DOI
10.1007/BF00426744
Publisher site
See Article on Publisher Site

Abstract

213 57 57 3 3 David Frankel Jatinder M. Khanna Harold Kalant A. Eugene LeBlanc Department of Pharmacology University of Toronto, and Addiction Research Foundation of Ontario M5S 1A8 Toronto Canada Abstract Daily administration of ethanol in a liquid diet or by intubation were both effective in producing tolerance to the hypothermic effects of ethanol. When p -chlorophenylalanine ( p -CPA) was administered in a dose previously demonstrated to maintain extensive brain serotonin (5-HT) depletion, the temperature-lowering effects of ethanol were less pronounced than in corresponding controls. The analysis of the effect of p -CPA on tolerance development took into account both initial body temperature and the degree of hypothermia. This study extends our findings with respect to the inhibitory effect of p -CPA on the development of tolerance to the motor-impairing effects of ethanol, and suggests that 5-HT may have a role in tolerance development to ethanol.

Journal

PsychopharmacologySpringer Journals

Published: Jan 1, 1978

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