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Effect in bronchial asthma of a new beta-adrenergic blocking drug atenolol (ICI 66, 082)

Effect in bronchial asthma of a new beta-adrenergic blocking drug atenolol (ICI 66, 082) 228 11 11 1 1 N. P. Boye J. R. Vale University Department of Lung Diseases, Rikshospitalet Oslo Norway Summary The bronchial effect of intravenous atenolol (ICI 66.082) has been studied in a doubleblind cross over trial in 10 patients with pronounced, labile bronchial asthma. A single i. v. dose of atenolol 3 mg, sufficient to cause a fall in heart rate and systolic blood pressure at rest, induced only a slight and clinically almost negligible impairment of ventilatory function. An ordinary therapeutic dose of salbutamol by inhalation far outweighed the bronchial effect of atenolol. The drug appears promising with regard to its cardio-selective properties. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Clinical Pharmacology Springer Journals

Effect in bronchial asthma of a new beta-adrenergic blocking drug atenolol (ICI 66, 082)

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References (12)

Publisher
Springer Journals
Copyright
Copyright © 1977 by Springer-Verlag
Subject
Biomedicine; Pharmacology/Toxicology
ISSN
0031-6970
eISSN
1432-1041
DOI
10.1007/BF00561781
Publisher site
See Article on Publisher Site

Abstract

228 11 11 1 1 N. P. Boye J. R. Vale University Department of Lung Diseases, Rikshospitalet Oslo Norway Summary The bronchial effect of intravenous atenolol (ICI 66.082) has been studied in a doubleblind cross over trial in 10 patients with pronounced, labile bronchial asthma. A single i. v. dose of atenolol 3 mg, sufficient to cause a fall in heart rate and systolic blood pressure at rest, induced only a slight and clinically almost negligible impairment of ventilatory function. An ordinary therapeutic dose of salbutamol by inhalation far outweighed the bronchial effect of atenolol. The drug appears promising with regard to its cardio-selective properties.

Journal

European Journal of Clinical PharmacologySpringer Journals

Published: Jan 1, 1977

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