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Diterpenoid alkaloids as a new class of antiarrhythmic agents. Structure-activity relationship

Diterpenoid alkaloids as a new class of antiarrhythmic agents. Structure-activity relationship The cardiotropic activities of 111 diterpene alkaloids and their synthetic derivatives having lycoctine, heteratisine, napelline, and denudatine skeletons have been studied. It has been established that the overwhelming majority of these compounds exhibit a pronounced antiarrhythmic and antifibrillatory action, which is a finding of practical interest. Their structure-activity relationships — the directions of their action in relation to the results of x-ray structural analysis — have been investigated. The following have been selected and proposed as antiarrhythmic agents for practical medicine: lappaconitine, deacetyllappaconitine, 6-benzoylheteratisine, 14-benzoyl talatisamine, 1-benzoylnapelline, and others. Of them, lappaconitine hydrobromide (allapinin) has been introduced into public health practice. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Chemistry of Natural Compounds Springer Journals

Diterpenoid alkaloids as a new class of antiarrhythmic agents. Structure-activity relationship

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References (7)

Publisher
Springer Journals
Copyright
Copyright © 1997 by Plenum Publishing Corporation
Subject
Pharmacy; Organic Chemistry; Pharmacy; Plant Sciences
ISSN
0009-3130
eISSN
1573-8388
DOI
10.1007/BF02291540
Publisher site
See Article on Publisher Site

Abstract

The cardiotropic activities of 111 diterpene alkaloids and their synthetic derivatives having lycoctine, heteratisine, napelline, and denudatine skeletons have been studied. It has been established that the overwhelming majority of these compounds exhibit a pronounced antiarrhythmic and antifibrillatory action, which is a finding of practical interest. Their structure-activity relationships — the directions of their action in relation to the results of x-ray structural analysis — have been investigated. The following have been selected and proposed as antiarrhythmic agents for practical medicine: lappaconitine, deacetyllappaconitine, 6-benzoylheteratisine, 14-benzoyl talatisamine, 1-benzoylnapelline, and others. Of them, lappaconitine hydrobromide (allapinin) has been introduced into public health practice.

Journal

Chemistry of Natural Compounds – Springer Journals

Published: Dec 29, 2005

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