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Cytogenetic investigations on children with acute non-lymphocytic leukemia

Cytogenetic investigations on children with acute non-lymphocytic leukemia 277 56 56 6 6 E. Oláh E. Balogh J. Szollár É. Szakmáry I. Kovács D. Schuler L. Karmazsin Pediatric Department Medical School POB 32 H-4012 Debrecen Hungary Second Pediatric Department Medical School Budapest Hungary Summary Cytogenetic data from 30 children with acute non-lymphocytic leukemia (ANLL) are evaluated in connection with patient's age, morphological type of leukemia and prognosis. In 20 out of 30 patients clonal chromosome aberrations were found. The frequency of chromosome aberrations and the prognostic parameters in the various morphological and age groups proved to be different and no direct relationship could be found in a given group between the frequency of aberrations and the prognosis. A more detailed analysis of data, however, provided some evidence that chromosome aberrations observed at diagnosis had a prognostic value independent of age and the morphological properties of blast cells: the normal karyotype and the pseudodiploidy proved to be of a favorable value but the hyperdiploidy and polyploidy an unfavorable prognostic parameter. Besides the known cytogenetic differences between childhood and adult ANLL, some similarities are also emphasized. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Hematology Springer Journals

Cytogenetic investigations on children with acute non-lymphocytic leukemia

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References (34)

Publisher
Springer Journals
Copyright
Copyright © 1988 by Springer-Verlag
Subject
Medicine & Public Health; Hematology; Oncology
ISSN
0939-5555
eISSN
1432-0584
DOI
10.1007/BF00320283
Publisher site
See Article on Publisher Site

Abstract

277 56 56 6 6 E. Oláh E. Balogh J. Szollár É. Szakmáry I. Kovács D. Schuler L. Karmazsin Pediatric Department Medical School POB 32 H-4012 Debrecen Hungary Second Pediatric Department Medical School Budapest Hungary Summary Cytogenetic data from 30 children with acute non-lymphocytic leukemia (ANLL) are evaluated in connection with patient's age, morphological type of leukemia and prognosis. In 20 out of 30 patients clonal chromosome aberrations were found. The frequency of chromosome aberrations and the prognostic parameters in the various morphological and age groups proved to be different and no direct relationship could be found in a given group between the frequency of aberrations and the prognosis. A more detailed analysis of data, however, provided some evidence that chromosome aberrations observed at diagnosis had a prognostic value independent of age and the morphological properties of blast cells: the normal karyotype and the pseudodiploidy proved to be of a favorable value but the hyperdiploidy and polyploidy an unfavorable prognostic parameter. Besides the known cytogenetic differences between childhood and adult ANLL, some similarities are also emphasized.

Journal

Annals of HematologySpringer Journals

Published: Jun 1, 1988

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