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Coronary heart disease and urinary albumin excretion rate in Type 2 (non-insulin-dependent) diabetic patients

Coronary heart disease and urinary albumin excretion rate in Type 2 (non-insulin-dependent)... 125 31 31 2 2 M. B. Mattock H. Keen G. C. Viberti M. R. El-Gohari T. J. Murrells G. S. Scott J. R. Wing P. G. Jackson Unit for Metabolic Medicine United Medical Schools of Guy's and St Thomas' Hospitals London Clinical Epidemiology and Public Health Research Unit Robens Institute, University of Surrey Guildford Surrey Lewisham Hospital London UK Summary Associations between overnight urinary albumin excretion rate and prevalent coronary heart disease and its major risk factors were examined in a cross-sectional study of 141 Type 2 (non-insulin-dependent) diabetic patients. Mean albumin excretion rate was higher in men (geometric mean 13.5 μg/min; 95% confidence interval 10.3–17.6) than women (7.5 μg/min; 5.7–9.8, p <0.01). In diabetic men and women mean albumin excretion rate was higher in those with electrocardiographic and/or symptomatic evidence of coronary heart disease than in those without (men, 23.1 μg/ min; 95% confidence interval 13.7–39.0 versus 10.6 μg/min; 7.9–14.2, p <0.01, women, 13.7 μg/min; 8.0–23.5 versus 5.4 μg/min; 4.2–6.8, p <0.01). Multiple logistic regression analysis was used to allow for confounding between variables. In the diabetic group as a whole, raised albumin excretion rate ( p <0.001), gender ( p <0.05) and systolic blood pressure ( p =0.06) entered the “best” model for coronary heart disease prediction. In women, albumin excretion rate alone ( p <0.01) and in men albumin excretion rate ( p <0.01) and age ( p =0.05) entered the “best” models. We conclude that albumin excretion rate is significantly associated with coronary heart disease morbidity after taking into account the confounding effects of raised blood pressure and other cardiovascular risk factors. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Diabetologia Springer Journals

Coronary heart disease and urinary albumin excretion rate in Type 2 (non-insulin-dependent) diabetic patients

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References (23)

Publisher
Springer Journals
Copyright
Copyright © 1988 by Springer-Verlag
Subject
Medicine & Public Health; Human Physiology; Internal Medicine; Metabolic Diseases
ISSN
0012-186X
eISSN
1432-0428
DOI
10.1007/BF00395552
Publisher site
See Article on Publisher Site

Abstract

125 31 31 2 2 M. B. Mattock H. Keen G. C. Viberti M. R. El-Gohari T. J. Murrells G. S. Scott J. R. Wing P. G. Jackson Unit for Metabolic Medicine United Medical Schools of Guy's and St Thomas' Hospitals London Clinical Epidemiology and Public Health Research Unit Robens Institute, University of Surrey Guildford Surrey Lewisham Hospital London UK Summary Associations between overnight urinary albumin excretion rate and prevalent coronary heart disease and its major risk factors were examined in a cross-sectional study of 141 Type 2 (non-insulin-dependent) diabetic patients. Mean albumin excretion rate was higher in men (geometric mean 13.5 μg/min; 95% confidence interval 10.3–17.6) than women (7.5 μg/min; 5.7–9.8, p <0.01). In diabetic men and women mean albumin excretion rate was higher in those with electrocardiographic and/or symptomatic evidence of coronary heart disease than in those without (men, 23.1 μg/ min; 95% confidence interval 13.7–39.0 versus 10.6 μg/min; 7.9–14.2, p <0.01, women, 13.7 μg/min; 8.0–23.5 versus 5.4 μg/min; 4.2–6.8, p <0.01). Multiple logistic regression analysis was used to allow for confounding between variables. In the diabetic group as a whole, raised albumin excretion rate ( p <0.001), gender ( p <0.05) and systolic blood pressure ( p =0.06) entered the “best” model for coronary heart disease prediction. In women, albumin excretion rate alone ( p <0.01) and in men albumin excretion rate ( p <0.01) and age ( p =0.05) entered the “best” models. We conclude that albumin excretion rate is significantly associated with coronary heart disease morbidity after taking into account the confounding effects of raised blood pressure and other cardiovascular risk factors.

Journal

DiabetologiaSpringer Journals

Published: Feb 1, 1988

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