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Comparison of behavioral and cardiovascular effects of l -DOPA and 5-HTP in conscious dogs

Comparison of behavioral and cardiovascular effects of l -DOPA and 5-HTP in conscious dogs 213 26 26 2 2 B. Dunkley I. Sanghvi E. Friedman S. Gershon Neuropsychopharmacology Research Unit Department of Psychiatry New York University Medical Center New York Abstract Moderate doses of l -DOPA (30–40 mg/kg) alone produced depressant effects, emesis and a mild hypertensive response in dogs. These depressant effects included decreased alertness, reduced response to overt stimuli such as whistling or sharp noises, reduced response to handling and a degree of flaccidity. Haloperidol completely blocked the behavioral and emetic effects of l -DOPA and, in most cases, significantly reduced the hypertensive response. Methysergide prevented the depressive effects and significantly attenuated emesis but had variable effect on the hypertensive response of l -DOPA. HMD and Ro 4-4062, in doses which selectively inhibit peripheral decarboxylase, completely blocked most of the behavioral effects, markedly attenuated emesis and prevented or reduced the hypertensive response, of l -DOPA. HMD, in addition, converted the hypertensive response of l -DOPA to a hypotensive response. dl -Parachlorophenylalanine completely blocked the behavioral effects and significantly reduced the cardiovascular effect of l -DOPA but had no effect on emesis induced by l -DOPA. dl -5-HTP, in contrast to l -DOPA, produced behavioral excitation in the dogs. It also produced a hypertensive response. Haloperidol had no significnat effect on the behavioral responses but significantly reduced the cardiovascular response produced by dl -5-HTP. Methysergide, similarly, had no significant effect on the behavioral responses of dl -5-HTP but had variable effects on the hypertensive response. Ro 4-4602 and HMD also had no effect on the behavioral and cardiovascular responses due to dl -5-HTP. l -DOPA failed to prevent the behavioral effects of 5-HTP. 5-HTP completely blocked or significantly attenuated the emetic response produced by l -DOPA although there was no significant change in the blood pressure when compared with controls. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychopharmacology Springer Journals

Comparison of behavioral and cardiovascular effects of l -DOPA and 5-HTP in conscious dogs

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References (23)

Publisher
Springer Journals
Copyright
Copyright © 1972 by Springer-Verlag
Subject
Biomedicine; Pharmacology/Toxicology; Psychiatry
ISSN
0033-3158
eISSN
1432-2072
DOI
10.1007/BF00422103
Publisher site
See Article on Publisher Site

Abstract

213 26 26 2 2 B. Dunkley I. Sanghvi E. Friedman S. Gershon Neuropsychopharmacology Research Unit Department of Psychiatry New York University Medical Center New York Abstract Moderate doses of l -DOPA (30–40 mg/kg) alone produced depressant effects, emesis and a mild hypertensive response in dogs. These depressant effects included decreased alertness, reduced response to overt stimuli such as whistling or sharp noises, reduced response to handling and a degree of flaccidity. Haloperidol completely blocked the behavioral and emetic effects of l -DOPA and, in most cases, significantly reduced the hypertensive response. Methysergide prevented the depressive effects and significantly attenuated emesis but had variable effect on the hypertensive response of l -DOPA. HMD and Ro 4-4062, in doses which selectively inhibit peripheral decarboxylase, completely blocked most of the behavioral effects, markedly attenuated emesis and prevented or reduced the hypertensive response, of l -DOPA. HMD, in addition, converted the hypertensive response of l -DOPA to a hypotensive response. dl -Parachlorophenylalanine completely blocked the behavioral effects and significantly reduced the cardiovascular effect of l -DOPA but had no effect on emesis induced by l -DOPA. dl -5-HTP, in contrast to l -DOPA, produced behavioral excitation in the dogs. It also produced a hypertensive response. Haloperidol had no significnat effect on the behavioral responses but significantly reduced the cardiovascular response produced by dl -5-HTP. Methysergide, similarly, had no significant effect on the behavioral responses of dl -5-HTP but had variable effects on the hypertensive response. Ro 4-4602 and HMD also had no effect on the behavioral and cardiovascular responses due to dl -5-HTP. l -DOPA failed to prevent the behavioral effects of 5-HTP. 5-HTP completely blocked or significantly attenuated the emetic response produced by l -DOPA although there was no significant change in the blood pressure when compared with controls.

Journal

Psychopharmacology – Springer Journals

Published: Jun 1, 1972

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