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Comparability of retention indices of polar substances at elevated temperatures

Comparability of retention indices of polar substances at elevated temperatures The non-linear dependency of the retention indices of drugs on temperature is demonstrated hence an indication of the actual working temperature is essential. Fixed temperatures for the determination of retention indices of drugs are proposed. Interlaboratory comparisons of the retention indices of 14 drugs frequently encountered in analytical practice are made for the first time on two stationary phases in three laboratories and on four GC apparatus. The data show that, in comparison with literature values, the interlaboratory deviation is reduced by 1/3 to 1/2 if same temperatures are used. Standardization of the temperature of determination of the retention indices of drugs and unknown substances in biological specimens on OV-1 and OV-17 is proposed. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Chromatographia Springer Journals

Comparability of retention indices of polar substances at elevated temperatures

Chromatographia , Volume 9 (7) – Jul 1, 1976

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References (16)

Publisher
Springer Journals
Copyright
Copyright © 1976 by Friedr. Vieweg & Sohn Verlagschesellschaft mbH
Subject
Chemistry; Analytical Chemistry; Organic Chemistry; Biochemistry, general; Plant Sciences; Pharmacy; Measurement Science, Instrumentation
ISSN
0009-5893
eISSN
1612-1112
DOI
10.1007/BF02268832
Publisher site
See Article on Publisher Site

Abstract

The non-linear dependency of the retention indices of drugs on temperature is demonstrated hence an indication of the actual working temperature is essential. Fixed temperatures for the determination of retention indices of drugs are proposed. Interlaboratory comparisons of the retention indices of 14 drugs frequently encountered in analytical practice are made for the first time on two stationary phases in three laboratories and on four GC apparatus. The data show that, in comparison with literature values, the interlaboratory deviation is reduced by 1/3 to 1/2 if same temperatures are used. Standardization of the temperature of determination of the retention indices of drugs and unknown substances in biological specimens on OV-1 and OV-17 is proposed.

Journal

ChromatographiaSpringer Journals

Published: Jul 1, 1976

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