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Cocaine as a discriminative cue in rats: Interactions with neuroleptics and other drugs

Cocaine as a discriminative cue in rats: Interactions with neuroleptics and other drugs 213 59 59 2 2 Torbjörn U. C. Järbe Department of Psychology University of Uppsala P.O. Box 227 S-75104 Uppsala 1 Sweden Abstract Rats were trained to discriminate between the effects of 4 mg/kg of cocaine HCl and saline (1 ml/kg) in a T-shaped maze. When the animals reliably differentiated the imposed training conditions (cocaine vs. no drug), test sessions were interspersed in between the regular training sessions. Test trials resulted in a median effective dose (ED 50 ) of 1.6 mg/kg of cocaine, and the duration of the discriminable effects of cocaine in producing 50% cocaine-appropriate responding was 57.9 min postinjection. Pretreatment with neuroleptics (pimozide, haloperidol, and chlorpromazine), but not with propranolol, phenoxybenzamine, alphamethyl-para-tyrosine, or physostigmine, attenuated the cocaine discrimination. Data are discussed with reference to previous results from amphetamine discriminations. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychopharmacology Springer Journals

Cocaine as a discriminative cue in rats: Interactions with neuroleptics and other drugs

Järbe, Torbjörn
Psychopharmacology , Volume 59 (2) – Jan 1, 1978
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References (34)

Publisher
Springer Journals
Copyright
Copyright © 1978 by Springer-Verlag
Subject
Biomedicine; Pharmacology/Toxicology; Psychiatry
ISSN
0033-3158
eISSN
1432-2072
DOI
10.1007/BF00427755
Publisher site
See Article on Publisher Site

Abstract

213 59 59 2 2 Torbjörn U. C. Järbe Department of Psychology University of Uppsala P.O. Box 227 S-75104 Uppsala 1 Sweden Abstract Rats were trained to discriminate between the effects of 4 mg/kg of cocaine HCl and saline (1 ml/kg) in a T-shaped maze. When the animals reliably differentiated the imposed training conditions (cocaine vs. no drug), test sessions were interspersed in between the regular training sessions. Test trials resulted in a median effective dose (ED 50 ) of 1.6 mg/kg of cocaine, and the duration of the discriminable effects of cocaine in producing 50% cocaine-appropriate responding was 57.9 min postinjection. Pretreatment with neuroleptics (pimozide, haloperidol, and chlorpromazine), but not with propranolol, phenoxybenzamine, alphamethyl-para-tyrosine, or physostigmine, attenuated the cocaine discrimination. Data are discussed with reference to previous results from amphetamine discriminations.

Journal

Psychopharmacology – Springer Journals

Published: Jan 1, 1978

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