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Characterization of rabies virus from a human case in Nepal

Characterization of rabies virus from a human case in Nepal Rabies is endemic throughout most of Asia, with the majority of human cases transmitted by domestic dogs ( Canis familiaris ). Here, we report a case of rabies in a 12-year-old girl in the Lalitpur district of Nepal that might have been prevented by better public awareness and timely post-exposure prophylaxis. Molecular characterization of the virus showed 100% identity over a partial nucleoprotein gene sequence to previous isolates from Nepal belonging to the ‘arctic-like’ lineage of rabies virus. Sequence analysis of both partial nucleoprotein and glycoprotein genes showed differences in consensus sequence after passage in vitro but not after passage in vivo . http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

Characterization of rabies virus from a human case in Nepal

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References (16)

Publisher
Springer Journals
Copyright
Copyright © 2011 by Springer-Verlag
Subject
Biomedicine; Infectious Diseases; Medical Microbiology ; Virology
ISSN
0304-8608
eISSN
1432-8798
DOI
10.1007/s00705-010-0868-9
pmid
21298457
Publisher site
See Article on Publisher Site

Abstract

Rabies is endemic throughout most of Asia, with the majority of human cases transmitted by domestic dogs ( Canis familiaris ). Here, we report a case of rabies in a 12-year-old girl in the Lalitpur district of Nepal that might have been prevented by better public awareness and timely post-exposure prophylaxis. Molecular characterization of the virus showed 100% identity over a partial nucleoprotein gene sequence to previous isolates from Nepal belonging to the ‘arctic-like’ lineage of rabies virus. Sequence analysis of both partial nucleoprotein and glycoprotein genes showed differences in consensus sequence after passage in vitro but not after passage in vivo .

Journal

Archives of VirologySpringer Journals

Published: Apr 1, 2011

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