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Changes in morphine self-administration and morphine dependence after lesions of the caudate nucleus in rats

Changes in morphine self-administration and morphine dependence after lesions of the caudate... 213 41 41 3 3 S. D. Glick R. S. Cox A. M. Crane Department of Pharmacology, Mount Sinai School of Medicine City University of New York New York Abstract Rats were trained to bar press for intravenous infusions of morphine sulfate during 1-hr daily test sessions. Small, centrally placed bilateral lesions of the caudate nucleus reduced rates of morphine self-administration to approximately one seventh of preoperative levels; postoperative rates were similar to preoperative rates when the postoperative unit infusion dose of morphine was one tenth of the preoperative dose. Caudate lesions also lowered the threshold dose at which morphine's rewarding property could be detected. Physical dependence was studied in other rats receiving a 3-day continuous infusion of morphine sulfate via implanted subcutaneous silicone reservoirs. Caudate lesions ameliorated withdrawal-induced weight loss and naloxone-induced “wet dog shakes”. Both the self-administration and dependence data are consistent with the idea that morphine blocks dopaminergic transmission in the striatum. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychopharmacology Springer Journals

Changes in morphine self-administration and morphine dependence after lesions of the caudate nucleus in rats

Glick, S.; Cox, R.; Crane, A.
Psychopharmacology , Volume 41 (3) – Jan 1, 1975
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References (12)

Publisher
Springer Journals
Copyright
Copyright © 1975 by Springer-Verlag
Subject
Biomedicine; Pharmacology/Toxicology; Psychiatry
ISSN
0033-3158
eISSN
1432-2072
DOI
10.1007/BF00428927
Publisher site
See Article on Publisher Site

Abstract

213 41 41 3 3 S. D. Glick R. S. Cox A. M. Crane Department of Pharmacology, Mount Sinai School of Medicine City University of New York New York Abstract Rats were trained to bar press for intravenous infusions of morphine sulfate during 1-hr daily test sessions. Small, centrally placed bilateral lesions of the caudate nucleus reduced rates of morphine self-administration to approximately one seventh of preoperative levels; postoperative rates were similar to preoperative rates when the postoperative unit infusion dose of morphine was one tenth of the preoperative dose. Caudate lesions also lowered the threshold dose at which morphine's rewarding property could be detected. Physical dependence was studied in other rats receiving a 3-day continuous infusion of morphine sulfate via implanted subcutaneous silicone reservoirs. Caudate lesions ameliorated withdrawal-induced weight loss and naloxone-induced “wet dog shakes”. Both the self-administration and dependence data are consistent with the idea that morphine blocks dopaminergic transmission in the striatum.

Journal

Psychopharmacology – Springer Journals

Published: Jan 1, 1975

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