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Cellular aggregate size as the critical factor for flavonoid production by suspension cultures of Saussurea medusa

Cellular aggregate size as the critical factor for flavonoid production by suspension cultures of... Three previously established cell lines (yellow, red and white) of Saussurea medusa were investigated for jaceosidin and hispidulin production. Maximum yields of the jaceosidin and hispidulin were obtained in the red cell line at 75 ± 0.41 and 6.4 ± 0.31 mg l-1. Production of jaceosidin and hispidulin correlated with the sizes of compact callus aggregates (CCA) and cellular viability. In the red cell line, the sizes of CCA were predominantly of 2–4mm diameter and accounted for 64% biomass. This line had a sustained cell viability over 10 successive sub-cultures. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Biotechnology Letters Springer Journals

Cellular aggregate size as the critical factor for flavonoid production by suspension cultures of Saussurea medusa

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References (14)

Publisher
Springer Journals
Copyright
Copyright © 2005 by Springer
Subject
Chemistry; Biotechnology; Applied Microbiology; Biochemistry, general; Microbiology
ISSN
0141-5492
eISSN
1573-6776
DOI
10.1007/s10529-004-6934-1
pmid
15703870
Publisher site
See Article on Publisher Site

Abstract

Three previously established cell lines (yellow, red and white) of Saussurea medusa were investigated for jaceosidin and hispidulin production. Maximum yields of the jaceosidin and hispidulin were obtained in the red cell line at 75 ± 0.41 and 6.4 ± 0.31 mg l-1. Production of jaceosidin and hispidulin correlated with the sizes of compact callus aggregates (CCA) and cellular viability. In the red cell line, the sizes of CCA were predominantly of 2–4mm diameter and accounted for 64% biomass. This line had a sustained cell viability over 10 successive sub-cultures.

Journal

Biotechnology LettersSpringer Journals

Published: Nov 30, 2004

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