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213 124 124 3 3 A. G. Phillips P. Di Ciano Department of Psychology University of British Columbia 2136 West Mall V6T 1Z4 Vancouver B.C. Canada Abstract Rats were prepared with jugular catheters and assigned randomly to one of three groups: intravenous (IV) self-administration of cocaine, yoked administration of cocaine or vehicle. Rats experienced intermittent administration of cocaine (0.75 mg/kg per injection) or vehicle (0.1 ml/injection) for six test sessions, in accordance with the pattern of injections made by the self-administration group. Sensitization of motor activity between pre-and post-treatment challenges of cocaine (3 mg/kg, IV) was observed after both self- and yoked administration of cocaine but not in the yoked-vehicle group. These data indicate that sensitization as a consequence of drug self-administration may be an important factor in the etiology of addiction.
Psychopharmacology – Springer Journals
Published: Apr 1, 1996
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