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Behavioral sensitization is induced by intravenous self-administration of cocaine by rats

Behavioral sensitization is induced by intravenous self-administration of cocaine by rats 213 124 124 3 3 A. G. Phillips P. Di Ciano Department of Psychology University of British Columbia 2136 West Mall V6T 1Z4 Vancouver B.C. Canada Abstract Rats were prepared with jugular catheters and assigned randomly to one of three groups: intravenous (IV) self-administration of cocaine, yoked administration of cocaine or vehicle. Rats experienced intermittent administration of cocaine (0.75 mg/kg per injection) or vehicle (0.1 ml/injection) for six test sessions, in accordance with the pattern of injections made by the self-administration group. Sensitization of motor activity between pre-and post-treatment challenges of cocaine (3 mg/kg, IV) was observed after both self- and yoked administration of cocaine but not in the yoked-vehicle group. These data indicate that sensitization as a consequence of drug self-administration may be an important factor in the etiology of addiction. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychopharmacology Springer Journals

Behavioral sensitization is induced by intravenous self-administration of cocaine by rats

Psychopharmacology , Volume 124 (3) – Apr 1, 1996

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References (12)

Publisher
Springer Journals
Copyright
Copyright © 1996 by Springer-Verlag
Subject
Biomedicine; Pharmacology/Toxicology; Psychiatry
ISSN
0033-3158
eISSN
1432-2072
DOI
10.1007/BF02246669
Publisher site
See Article on Publisher Site

Abstract

213 124 124 3 3 A. G. Phillips P. Di Ciano Department of Psychology University of British Columbia 2136 West Mall V6T 1Z4 Vancouver B.C. Canada Abstract Rats were prepared with jugular catheters and assigned randomly to one of three groups: intravenous (IV) self-administration of cocaine, yoked administration of cocaine or vehicle. Rats experienced intermittent administration of cocaine (0.75 mg/kg per injection) or vehicle (0.1 ml/injection) for six test sessions, in accordance with the pattern of injections made by the self-administration group. Sensitization of motor activity between pre-and post-treatment challenges of cocaine (3 mg/kg, IV) was observed after both self- and yoked administration of cocaine but not in the yoked-vehicle group. These data indicate that sensitization as a consequence of drug self-administration may be an important factor in the etiology of addiction.

Journal

PsychopharmacologySpringer Journals

Published: Apr 1, 1996

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