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Basic biology of clozapine: electrophysiological and neuroendocrinological studies

Basic biology of clozapine: electrophysiological and neuroendocrinological studies 213 99 99 1 1 Gary A. Gudelsky J. Frank Nash Sally A. Berry Herbert Y. Meltzer Departments of Psychiatry and Pharmacology Case Western Reserve University, School of Medicine, Laboratory of Biological Psychiatry 2040 Abington Road 44106 Cleveland OH USA Abstract The effects of clozapine and other purported atypical antipsychotics were compared with those of typical antipsychotics within the neuroendocrine axis of the rat. Atypical antipsychotics (e.g., clozapine, thioridazine, melperone, setoperone and RMI 81582) differed from typical antipsychotics (e.g., haloperidol, chlorpromazine, cis -flupentixol and fluphenazine) in that they produced only a brief elevation in serum concentrations of prolactin but marked increases in serum or plasma concentrations of corticosterone and ACTH. Moreover, atypical antipsychotics, but not typical antipsychotics, acutely increased the activity of tuberoinfundibular dopamine neurons, as judged from the accumulation of DOPA in the median eminence after inhibition of decarboxylase activity. The effects of atypical antipsychotics on tuberoinfundibular dopamine neurons and corticosterone secretion were mimicked by neurotensin. It would appear that atypical antipsychotics elicit unique neuroendocrine responses that differentiate these agents from typical antipsychotic drugs. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychopharmacology Springer Journals

Basic biology of clozapine: electrophysiological and neuroendocrinological studies

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References (44)

Publisher
Springer Journals
Copyright
Copyright © 1989 by Springer-Verlag
Subject
Biomedicine; Pharmacology/Toxicology; Psychiatry
ISSN
0033-3158
eISSN
1432-2072
DOI
10.1007/BF00442553
Publisher site
See Article on Publisher Site

Abstract

213 99 99 1 1 Gary A. Gudelsky J. Frank Nash Sally A. Berry Herbert Y. Meltzer Departments of Psychiatry and Pharmacology Case Western Reserve University, School of Medicine, Laboratory of Biological Psychiatry 2040 Abington Road 44106 Cleveland OH USA Abstract The effects of clozapine and other purported atypical antipsychotics were compared with those of typical antipsychotics within the neuroendocrine axis of the rat. Atypical antipsychotics (e.g., clozapine, thioridazine, melperone, setoperone and RMI 81582) differed from typical antipsychotics (e.g., haloperidol, chlorpromazine, cis -flupentixol and fluphenazine) in that they produced only a brief elevation in serum concentrations of prolactin but marked increases in serum or plasma concentrations of corticosterone and ACTH. Moreover, atypical antipsychotics, but not typical antipsychotics, acutely increased the activity of tuberoinfundibular dopamine neurons, as judged from the accumulation of DOPA in the median eminence after inhibition of decarboxylase activity. The effects of atypical antipsychotics on tuberoinfundibular dopamine neurons and corticosterone secretion were mimicked by neurotensin. It would appear that atypical antipsychotics elicit unique neuroendocrine responses that differentiate these agents from typical antipsychotic drugs.

Journal

PsychopharmacologySpringer Journals

Published: Mar 1, 1989

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