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Autocrine stimulation in colorectal carcinoma (CRC)

Autocrine stimulation in colorectal carcinoma (CRC) Many tumors co-express growth factors and their receptors; thus, the concept of autocrine secretion was proposed to explain the unrestrained growth of the malignant cells. Autocrine stimulation refers to positive autocrine secretion, which functions to stimulate cell growth. Many of the positive autocrine loops have been demonstrated in human colorectal carcinoma (CRC), which are considered to play an important role in the initiation and progression of the cancer. These autocrine loops provide information for prognostic markers and targets for biological therapies of CRC. Interruption of the autocrine loops could potentially inhibit malignant cell growth. The field is encouraging but further research is needed. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Medical Oncology Springer Journals

Autocrine stimulation in colorectal carcinoma (CRC)

Medical Oncology , Volume 21 (1) – Jun 2, 2007

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References (31)

Publisher
Springer Journals
Copyright
Copyright © 2004 by Humana Press Inc
Subject
Medicine & Public Health; Oncology; Medicine/Public Health, general; Internal Medicine
ISSN
1357-0560
eISSN
1559-131X
DOI
10.1385/MO:21:1:01
pmid
15034208
Publisher site
See Article on Publisher Site

Abstract

Many tumors co-express growth factors and their receptors; thus, the concept of autocrine secretion was proposed to explain the unrestrained growth of the malignant cells. Autocrine stimulation refers to positive autocrine secretion, which functions to stimulate cell growth. Many of the positive autocrine loops have been demonstrated in human colorectal carcinoma (CRC), which are considered to play an important role in the initiation and progression of the cancer. These autocrine loops provide information for prognostic markers and targets for biological therapies of CRC. Interruption of the autocrine loops could potentially inhibit malignant cell growth. The field is encouraging but further research is needed.

Journal

Medical OncologySpringer Journals

Published: Jun 2, 2007

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