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References (93)
-
A. Festa, A. Festa, A. Festa, R. D'Agostino, R. D’Agostino, R. D’Agostino, George Howard, George Howard, George Howard, L. Mykkänen, L. Mykkänen, L. Mykkänen, R. Tracy, R. Tracy, R. Tracy, S. Haffner, S. Haffner, S. Haffner (2000)
Inflammation and microalbuminuria in nondiabetic and type 2 diabetic subjects: The Insulin Resistance Atherosclerosis Study.Kidney international, 58 4
-
R. Böger, S. Bode-Böger, A. Szuba, P. Tsao, J. Chan, O. Tangphao, T. Blaschke, J. Cooke (1998)
Asymmetric dimethylarginine (ADMA): a novel risk factor for endothelial dysfunction: its role in hypercholesterolemia.Circulation, 98 18
-
C. Zoccali, F. Mallamaci, R. Maas, F. Benedetto, G. Tripepi, L. Malatino, A. Cataliotti, I. Bellanuova, R. Böger (2002)
Left ventricular hypertrophy, cardiac remodeling and asymmetric dimethylarginine (ADMA) in hemodialysis patients.Kidney international, 62 1
-
Y. Taniyama, K. Griendling (2003)
Reactive oxygen species in the vasculature: molecular and cellular mechanisms.Hypertension, 42 6
-
R. Foley, P. Parfrey, M. Sarnak (1998)
Clinical epidemiology of cardiovascular disease in chronic renal disease.American journal of kidney diseases : the official journal of the National Kidney Foundation, 32 5 Suppl 3
-
C. Stehouwer, Y. Smulders (2006)
Microalbuminuria and risk for cardiovascular disease: Analysis of potential mechanisms.Journal of the American Society of Nephrology : JASN, 17 8
-
L. Ruilope, V. Lahera, J. Rodicio, J. Romero (1994)
Participation of nitric oxide in the regulation of renal function: possible role in the genesis of arterial hypertension.Journal of hypertension, 12 6
-
D. Fliser, F. Kronenberg, J. Kielstein, C. Morath, S. Bode-Böger, H. Haller, E. Ritz (2005)
Asymmetric dimethylarginine and progression of chronic kidney disease: the mild to moderate kidney disease study.Journal of the American Society of Nephrology : JASN, 16 8
-
J McDermott (1976)
Studies on the catabolism of Ng-methylarginine, Ng, Ng-dimethylarginine and Ng, Ng-dimethylarginine in the rabbit.The Biochemical journal, 154 1
-
Jan Kielstein, S. Simmel, S. Bode-Böger, H. Roth, Heinrich Schmidt-Gayk, Hermann Haller, Danilo Fliser (2004)
Subpressor Dose Asymmetric Dimethylarginine Modulates Renal Function in Humans through Nitric Oxide Synthase InhibitionKidney and Blood Pressure Research, 27
-
R. Macallister, H. Parry, M. Kimoto, T. Ogawa, R. Russell, H. Hodson, G. Whitley, P. Vallance (1996)
Regulation of nitric oxide synthesis by dimethylarginine dimethylaminohydrolaseBritish Journal of Pharmacology, 119
-
Qing-feng Yin, Y. Xiong (2005)
Pravastatin Restores DDAH Activity and Endothelium-Dependent Relaxation of Rat Aorta After Exposure to Glycated ProteinJournal of Cardiovascular Pharmacology, 45
-
K. Matsuguma, S. Ueda, S. Yamagishi, Yuriko Matsumoto, Utako Kaneyuki, Ryo Shibata, Toshiko Fujimura, H. Matsuoka, M. Kimoto, S. Kato, T. Imaizumi, S. Okuda (2006)
Molecular mechanism for elevation of asymmetric dimethylarginine and its role for hypertension in chronic kidney disease.Journal of the American Society of Nephrology : JASN, 17 8
-
H. Miyazaki, H. Matsuoka, John Cooke, M. Usui, S. Ueda, S. Okuda, T. Imaizumi (1999)
Endogenous nitric oxide synthase inhibitor: a novel marker of atherosclerosis.Circulation, 99 9
-
C. Zoccali, S. Bode-Böger, F. Mallamaci, F. Benedetto, G. Tripepi, L. Malatino, A. Cataliotti, I. Bellanuova, I. Fermo, J. Frölich, R. Böger (2001)
Plasma concentration of asymmetrical dimethylarginine and mortality in patients with end-stage renal disease: a prospective studyThe Lancet, 358
-
R. Macallister, P. Vallance (1994)
Nitric oxide in essential and renal hypertension.Journal of the American Society of Nephrology : JASN, 5 4
-
P. Ravani, G. Tripepi, F. Malberti, S. Testa, F. Mallamaci, C. Zoccali (2005)
Asymmetrical dimethylarginine predicts progression to dialysis and death in patients with chronic kidney disease: a competing risks modeling approach.Journal of the American Society of Nephrology : JASN, 16 8
-
J. Cook, Jin-Hyung Lee, Zhi-Hong Yang, Christopher Krause, N. Herth, R. Hoffmann, S. Pestka (2006)
FBXO11/PRMT9, a new protein arginine methyltransferase, symmetrically dimethylates arginine residues.Biochemical and biophysical research communications, 342 2
-
J. Bech, C. Nielsen, E. Pedersen (1996)
Effects of systemic NO synthesis inhibition on RPF, GFR, UNa, and vasoactive hormones in healthy humans.The American journal of physiology, 270 5 Pt 2
-
Ken Lin, Akira Ito, T. Asagami, P. Tsao, S. Adimoolam, M. Kimoto, H. Tsuji, G. Reaven, J. Cooke (2002)
Impaired Nitric Oxide Synthase Pathway in Diabetes Mellitus: Role of Asymmetric Dimethylarginine and Dimethylarginine DimethylaminohydrolaseCirculation: Journal of the American Heart Association, 106
-
T. Deckert, B. Feldt-Rasmussen, K. Borch-Johnsen, T. Jensen, A. Kofoed‐Enevoldsen (1989)
Albuminuria reflects widespread vascular damageDiabetologia, 32
-
J. Jacobi, K. Sydow, G. Degenfeld, Ying Zhang, H. Dayoub, Bing-yin Wang, A. Patterson, M. Kimoto, H. Blau, J. Cooke (2005)
Overexpression of Dimethylarginine Dimethylaminohydrolase Reduces Tissue Asymmetric Dimethylarginine Levels and Enhances AngiogenesisCirculation, 111
-
Caroline Smith, G. Birdsey, S. Anthony, F. Arrigoni, J. Leiper, P. Vallance (2003)
Dimethylarginine dimethylaminohydrolase activity modulates ADMA levels, VEGF expression, and cell phenotype.Biochemical and biophysical research communications, 308 4
-
S. Ueda, S. Yamagishi, Utako Kaneyuki, S. Okuda (2008)
Asymmetric Dimethylarginine (ADMA) and Cardiovascular DiseaseVascular Disease Prevention, 3
-
Y. Kakimoto, S. Akazawa (1970)
Isolation and Identification of Ng,Ng- and Ng,N'g-Dimethylarginine, Nε-Mono-, Di-, and Trimethyllysine, and Glucosylgalactosyl- and Galactosyl-δ-hydroxylysine from Human UrineJournal of Biological Chemistry, 245
-
T Deckert, B Feldt-Rasmussen, K Borch-Johnsen, T Jensen, A Kofoed-Enevoldsen (1989)
Albuminuria reflects widespread vascular damage. The Steno hypothesisDiabetologia, 32
-
M. Kimoto, G. Whitley, H. Tsuji, T. Ogawa (1995)
Detection of NG,NGDimethylarginine Dimethylaminohydrolase in Human Tissues Using a Monoclonal AntibodyJournal of Biochemistry, 117
-
J. Gary, S. Clarke (1998)
RNA and protein interactions modulated by protein arginine methylation.Progress in nucleic acid research and molecular biology, 61
-
T. Murohara, T. Asahara, Marcy Silver, C. Bauters, H. Masuda, C. Kalka, M. Kearney, Donghui Chen, Dongfen Chen, J. Symes, M. Fishman, Paul Huang, J. Isner (1998)
Nitric oxide synthase modulates angiogenesis in response to tissue ischemia.The Journal of clinical investigation, 101 11
-
K. Amann, C. Wanner, E. Ritz (2006)
Cross-talk between the kidney and the cardiovascular system.Journal of the American Society of Nephrology : JASN, 17 8
-
Jaeho Lee, Joyce Sayegh, J. Daniel, S. Clarke, M. Bedford (2005)
PRMT8, a New Membrane-bound Tissue-specific Member of the Protein Arginine Methyltransferase Family*Journal of Biological Chemistry, 280
-
M. Usui, H. Matsuoka, H. Miyazaki, S. Ueda, S. Okuda, T. Imaizumi (1998)
Increased endogenous nitric oxide synthase inhibitor in patients with congestive heart failure.Life sciences, 62 26
-
J. Barzilay, D. Peterson, M. Cushman, S. Heckbert, J. Cao, C. Blaum, R. Tracy, R. Klein, D. Herrington (2004)
The relationship of cardiovascular risk factors to microalbuminuria in older adults with or without diabetes mellitus or hypertension: the cardiovascular health study.American journal of kidney diseases : the official journal of the National Kidney Foundation, 44 1
-
John Cooke (2000)
Does ADMA cause endothelial dysfunction?Arteriosclerosis, thrombosis, and vascular biology, 20 9
-
M. Kimoto, S. Miyatake, T. Sasagawa, H. Yamashita, M. Okita, T. Oka, T. Ogawa, H. Tsuji (1998)
Purification, cDNA cloning and expression of human NG,NG-dimethylarginine dimethylaminohydrolase.European journal of biochemistry, 258 2
-
V. Valkonen, Hannu Päivä, J. Salonen, T. Lakka, T. Lehtimäki, J. Laakso, R. Laaksonen (2001)
Risk of acute coronary events and serum concentration of asymmetrical dimethylarginineThe Lancet, 358
-
M. Arcos, C. Fujihara, A. Sesso, E. Prado, M. Prado, G. Nucci, R. Zatz (2000)
Mechanisms of albuminuria in the chronic nitric oxide inhibition model.American journal of physiology. Renal physiology, 279 6
-
Akira Ito, P. Tsao, S. Adimoolam, M. Kimoto, T. Ogawa, John Cooke (1999)
Novel mechanism for endothelial dysfunction: dysregulation of dimethylarginine dimethylaminohydrolase.Circulation, 99 24
-
A. Dominiczak, David Bohr (1995)
Nitric oxide and its putative role in hypertension.Hypertension, 25 6
-
C. Zoccali (2006)
Endothelial dysfunction and the kidney: emerging risk factors for renal insufficiency and cardiovascular outcomes in essential hypertension.Journal of the American Society of Nephrology : JASN, 17 4 Suppl 2
-
Sun Jee, L. Boulware, E. Guallar, I. Suh, Lawrence Appel, E. Miller (2005)
Direct, progressive association of cardiovascular risk factors with incident proteinuria: results from the Korea Medical Insurance Corporation (KMIC) study.Archives of internal medicine, 165 19
-
C. Zoccali, F. Benedetto, R. Maas, F. Mallamaci, G. Tripepi, L. Malatino, R. Böger (2002)
Asymmetric dimethylarginine, C-reactive protein, and carotid intima-media thickness in end-stage renal disease.Journal of the American Society of Nephrology : JASN, 13 2
-
Akira Ito, K. Egashira, T. Narishige, Kouhei Muramatsu, Akira Takeshita (2001)
Renin-angiotensin system is involved in the mechanism of increased serum asymmetric dimethylarginine in essential hypertension.Japanese circulation journal, 65 9
-
M. Nangaku (2005)
Chronic hypoxia and tubulointerstitial injury: a final common pathway to end-stage renal failure.Journal of the American Society of Nephrology : JASN, 17 1
-
K. Çağlar, M. Yılmaz, A. Sonmez, E. Çakır, A. Kaya, Cengizhan Acikel, T. Eyileten, M. Yenıcesu, Y. Oğuz, C. Bilgi, C. Oktenli, A. Vural, Carmine Zoccali (2006)
ADMA, proteinuria, and insulin resistance in non-diabetic stage I chronic kidney disease.Kidney international, 70 4
-
C. Zoccali, F. Mallamaci, P. Finocchiaro (2002)
Atherosclerotic renal artery stenosis: epidemiology, cardiovascular outcomes, and clinical prediction rules.Journal of the American Society of Nephrology : JASN, 13 Suppl 3
-
D. Harrison (1997)
Cellular and molecular mechanisms of endothelial cell dysfunction.The Journal of clinical investigation, 100 9
-
Mukut Sharma, E. McCarthy, V. Savin, E. Lianos (2005)
Nitric oxide preserves the glomerular protein permeability barrier by antagonizing superoxide.Kidney international, 68 6
-
Jonathan Himmelfarb, P. Stenvinkel, T. Ikizler, Raymond Hakim (2002)
The elephant in uremia: oxidant stress as a unifying concept of cardiovascular disease in uremia.Kidney international, 62 5
-
A. Jager, P. Kostense, H. Ruhé, R. Heine, G. Nijpels, J. Dekker, L. Bouter, C. Stehouwer (1999)
Microalbuminuria and peripheral arterial disease are independent predictors of cardiovascular and all-cause mortality, especially among hypertensive subjects: five-year follow-up of the Hoorn Study.Arteriosclerosis, thrombosis, and vascular biology, 19 3
-
Markus Stühlinger, P. Tsao, J. Her, M. Kimoto, R. Balint, J. Cooke (2001)
Homocysteine Impairs the Nitric Oxide Synthase Pathway: Role of Asymmetric DimethylarginineCirculation: Journal of the American Heart Association, 104
-
R. Böger, K. Sydow, J. Borlak, T. Thum, H. Lenzen, Bibiana Schubert, D. Tsikas, S. Bode-Böger (2000)
LDL cholesterol upregulates synthesis of asymmetrical dimethylarginine in human endothelial cells: involvement of S-adenosylmethionine-dependent methyltransferases.Circulation research, 87 2
-
T. Ogawa, M. Kimoto, K. Sasaoka (1987)
Occurrence of a new enzyme catalyzing the direct conversion of NG,NG-dimethyl-L-arginine to L-citrulline in rats.Biochemical and biophysical research communications, 148 2
-
D. Fliser, J. Kielstein, H. Haller, S. Bode-Böger (2003)
Asymmetric dimethylarginine: a cardiovascular risk factor in renal disease?Kidney international. Supplement, 84
-
K. Okubo, K. Hayashi, S. Wakino, H. Matsuda, E. Kubota, M. Honda, H. Tokuyama, Tokunori Yamamoto, F. Kajiya, T. Saruta (2005)
Role of Asymmetrical Dimethylarginine in Renal Microvascular Endothelial Dysfunction in Chronic Renal Failure with HypertensionHypertension Research, 28
-
G. Watts, S. Herrmann, G. Dogra, D. Playford, J. Best, M. Thomas, A. Irish (2001)
Vascular function of the peripheral circulation in patients with nephrosis.Kidney international, 60 1
-
D. Kang, T. Nakagawa, Lili Feng, Richard Johnson (2002)
Nitric oxide modulates vascular disease in the remnant kidney model.The American journal of pathology, 161 1
-
A. Leone, S. Moncada, Patrick Vallance, A. Calver, J. Collier (1992)
Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failureThe Lancet, 339
-
J. Kielstein, R. Böger, S. Bode-Böger, J. Frölich, H. Haller, E. Ritz, D. Fliser (2002)
Marked increase of asymmetric dimethylarginine in patients with incipient primary chronic renal disease.Journal of the American Society of Nephrology : JASN, 13 1
-
L. Fine, C. Orphanides, J. Norman (1998)
Progressive renal disease: the chronic hypoxia hypothesis.Kidney international. Supplement, 65
-
E. Marliss, S. Chevalier, R. Gougeon, J. Morais, M. Lamarche, O. Adegoke, Guoyao Wu (2006)
Elevations of plasma methylarginines in obesity and ageing are related to insulin sensitivity and rates of protein turnoverDiabetologia, 49
-
J. Ärnlöv, J. Evans, J. Meigs, Thomas Wang, C. Fox, D. Levy, E. Benjamin, R. D'Agostino, R. Vasan (2005)
Low-Grade Albuminuria and Incidence of Cardiovascular Disease Events in Nonhypertensive and Nondiabetic Individuals: The Framingham Heart StudyCirculation, 112
-
A. Erdely, Laszlo Wagner, Veronica Muller, Attila Szabo, C. Baylis (2003)
Protection of wistar furth rats from chronic renal disease is associated with maintained renal nitric oxide synthase.Journal of the American Society of Nephrology : JASN, 14 10
-
V. Kostourou, S. Robinson, Judith Cartwright, G. Whitley (2002)
Dimethylarginine dimethylaminohydrolase I enhances tumour growth and angiogenesisBritish Journal of Cancer, 87
-
S. Aslam, T. Sántha, A. Leone, C. Wilcox (2006)
Effects of amlodipine and valsartan on oxidative stress and plasma methylarginines in end-stage renal disease patients on hemodialysis.Kidney international, 70 12
-
R. Stocker, J. Keaney (2004)
Role of oxidative modifications in atherosclerosis.Physiological reviews, 84 4
-
Yuriko Matsumoto, S. Ueda, S. Yamagishi, K. Matsuguma, Ryo Shibata, K. Fukami, H. Matsuoka, T. Imaizumi, S. Okuda (2007)
Dimethylarginine dimethylaminohydrolase prevents progression of renal dysfunction by inhibiting loss of peritubular capillaries and tubulointerstitial fibrosis in a rat model of chronic kidney disease.Journal of the American Society of Nephrology : JASN, 18 5
-
T. Osanai, M. Saitoh, Satoko Sasaki, H. Tomita, T. Matsunaga, K. Okumura (2003)
Effect of Shear Stress on Asymmetric Dimethylarginine Release From Vascular Endothelial CellsHypertension: Journal of the American Heart Association, 42
-
Subrata Ghosh, W. Paik, Sangduk Kim (1988)
Purification and molecular identification of two protein methylases I from calf brain. Myelin basic protein- and histone-specific enzyme.The Journal of biological chemistry, 263 35
-
J. Arnal, J. Michel, D. Harrison (1995)
Nitric oxide in the pathogenesis of hypertension.Current opinion in nephrology and hypertension, 4 2
-
L. Tarnow, P. Hovind, T. Teerlink, C. Stehouwer, H. Parving (2004)
Elevated plasma asymmetric dimethylarginine as a marker of cardiovascular morbidity in early diabetic nephropathy in type 1 diabetes.Diabetes care, 27 3
-
C. Zoccali, F. Mallamaci, G. Tripepi (2004)
Novel cardiovascular risk factors in end-stage renal disease.Journal of the American Society of Nephrology : JASN, 15 Suppl 1
-
R. Macallister, S. Fickling, G. Whitley, P. Vallance (1994)
Metabolism of methylarginines by human vasculature; implications for the regulation of nitric oxide synthesisBritish Journal of Pharmacology, 112
-
T. Thum, D. Tsikas, Sylvia Stein, M. Schultheiss, M. Eigenthaler, S. Anker, P. Poole‐Wilson, G. Ertl, J. Bauersachs (2005)
Suppression of endothelial progenitor cells in human coronary artery disease by the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine.Journal of the American College of Cardiology, 46 9
-
S. Moncada, A. Higgs (1993)
The L-arginine-nitric oxide pathway.The New England journal of medicine, 329 27
-
H. Matsuoka, Shingo Itoh, Masumi Kimoto, K. Kohno, O. Tamai, Y. Wada, Hideo Yasukawa, Gensho Iwami, Seiya Okuda, Tsutomu Imaizumi (1997)
Asymmetrical dimethylarginine, an endogenous nitric oxide synthase inhibitor, in experimental hypertension.Hypertension, 29 1 Pt 2
-
S. Ueda, S. Kato, H. Matsuoka, M. Kimoto, S. Okuda, M. Morimatsu, T. Imaizumi (2003)
Regulation of Cytokine-Induced Nitric Oxide Synthesis by Asymmetric Dimethylarginine: Role of Dimethylarginine DimethylaminohydrolaseCirculation Research: Journal of the American Heart Association, 92
-
T. Guzik, Nicky West, E. Black, D. McDonald, C. Ratnatunga, R. Pillai, K. Channon (2000)
Vascular superoxide production by NAD(P)H oxidase: association with endothelial dysfunction and clinical risk factors.Circulation research, 86 9
-
T. Jafar, P. Stark, C. Schmid, M. Landa, G. Maschio, P. Jong, D. Zeeuw, S. Shahinfar, R. Toto, A. Levey (2003)
Progression of Chronic Kidney Disease: The Role of Blood Pressure Control, Proteinuria, and Angiotensin-Converting Enzyme Inhibition: A Patient-Level Meta-AnalysisAnnals of Internal Medicine, 139
-
S. Fickling, D. Holden, Judith Cartwright, S. Nussey, P. Vallance, G. Whitley (1999)
Regulation of macrophage nitric oxide synthesis by endothelial cells: a role for NG,NG-dimethylarginine.Acta physiologica Scandinavica, 167 2
-
P. Parfrey, R. Foley (1999)
The clinical epidemiology of cardiac disease in chronic renal failure.Journal of the American Society of Nephrology : JASN, 10 7
-
John Cooke, Victor Dzau (1997)
Derangements of the nitric oxide synthase pathway, L-arginine, and cardiovascular diseases.Circulation, 96 2
-
I. Schulman, Ming-Sheng Zhou, L. Raij (2005)
Nitric oxide, angiotensin II, and reactive oxygen species in hypertension and atherogenesisCurrent Hypertension Reports, 7
-
H. Dayoub, V. Achan, S. Adimoolam, J. Jacobi, M. Stuehlinger, Bing-yin Wang, P. Tsao, M. Kimoto, P. Vallance, A. Patterson, J. Cooke (2003)
Dimethylarginine Dimethylaminohydrolase Regulates Nitric Oxide Synthesis: Genetic and Physiological EvidenceCirculation: Journal of the American Heart Association, 108
-
C. Stehouwer (2004)
Endothelial dysfunction in diabetic nephropathy: state of the art and potential significance for non-diabetic renal disease.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 19 4
-
J. Leiper, Joanne Maria, A. Chubb, R. Macallister, Ian Charles, G. Whitley, Patrick Vallance (1999)
Identification of two human dimethylarginine dimethylaminohydrolases with distinct tissue distributions and homology with microbial arginine deiminases.The Biochemical journal, 343 Pt 1
-
R. Furchgott, J. Zawadzki (1980)
The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholineNature, 288
-
L. Millatt, G. Whitley, Dechun Li, J. Leiper, H. Siragy, R. Carey, R. Johns (2003)
Evidence for Dysregulation of Dimethylarginine Dimethylaminohydrolase I in Chronic Hypoxia–Induced Pulmonary HypertensionCirculation: Journal of the American Heart Association, 108
-
N. Rawal, R. Rajpurohit, W. Paik, Soochong Kim (1994)
Purification and characterization of S-adenosylmethionine-protein-arginine N-methyltransferase from rat liver.The Biochemical journal, 300 ( Pt 2)
-
S. Anthony, J. Leiper, P. Vallance (2005)
Endogenous production of nitric oxide synthase inhibitorsVascular Medicine, 10
-
J. Cross, A. Donald, Patrick Vallance, J. Deanfield, R. Woolfson, R. Macallister (2001)
Dialysis improves endothelial function in humans.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 16 9
-
S. Dinneen, H. Gerstein (1997)
The association of microalbuminuria and mortality in non-insulin-dependent diabetes mellitus. A systematic overview of the literature.Archives of internal medicine, 157 13
-
V. Achan, M. Broadhead, M. Malaki, G. Whitley, J. Leiper, R. Macallister, P. Vallance (2003)
Asymmetric Dimethylarginine Causes Hypertension and Cardiac Dysfunction in Humans and Is Actively Metabolized by Dimethylarginine DimethylaminohydrolaseArteriosclerosis, Thrombosis, and Vascular Biology: Journal of the American Heart Association, 23
- Publisher
- Springer Journals
- Copyright
- Copyright © 2007 by Japanese Society of Nephrology
- Subject
- Medicine & Public Health; Nephrology; Urology
- ISSN
- 1342-1751
- eISSN
- 1437-7799
- DOI
- 10.1007/s10157-007-0471-x
- pmid
- 17593510
- Publisher site
- See Article on Publisher Site
Abstract
Endothelial dysfunction due to the reduced bioavailability of nitric oxide (NO) is involved in the course of atherosclerotic cardiovascular disease as well as chronic kidney disease (CKD). NO is synthesized from L-arginine via the action of NO synthase, which is blocked by endogenous L-arginine analogues such as asymmetric dimethylarginine (ADMA). ADMA is a naturally occurring amino acid found in plasma and various types of tissues. The plasma level of ADMA is reported to be associated with cardiovascular risk factors such as hypertension, diabetes, hyperlipidemia, and CKD, and is a strong predictor for cardiovascular disease and the progression of CKD. In this review, we discuss the biology of ADMA, the molecular mechanisms of the elevation of ADMA levels in CKD, and the pathological role of ADMA in patients with CKD.
Journal
Clinical and Experimental Nephrology – Springer Journals
Published: Jun 1, 2007