Access the full text.
Sign up today, get DeepDyve free for 14 days.
B. Malhotra, R. Brundage, M. Lemaire, R. Sawchuk (1997)
Modeling the route of administration-based enhancement in the brain delivery of EAB 515, studied by microdialysis.Journal of drug targeting, 4 5
D. Deleu, S. Sarre, G. Ebinger, Y. Michotte (1995)
The effect of carbidopa and entacapone pretreatment on the L-dopa pharmacokinetics and metabolism in blood plasma and skeletal muscle in beagle dog: an in vivo microdialysis study.The Journal of pharmacology and experimental therapeutics, 273 3
S. Wages, W. Church, J. Justice (1986)
Sampling considerations for on-line microbore liquid chromatography of brain dialysate.Analytical chemistry, 58 8
F. Stain, M. Barjavel, P. Sandouk, M. Plotkine, J. Scherrmann, Hemendra Bhargava (1995)
Analgesic response and plasma and brain extracellular fluid pharmacokinetics of morphine and morphine-6-beta-D-glucuronide in the rat.The Journal of pharmacology and experimental therapeutics, 274 2
P. Jansson, U. Smith, P. Lönnroth (1990)
Interstitial glycerol concentration measured by microdialysis in two subcutaneous regions in humans.The American journal of physiology, 258 6 Pt 1
N. Kurata, M. Inagaki, S. Kobayashi, Y. Nishimura, K. Oguchi, H. Yasuhara (1993)
Antipyrine concentrations in liver and blood monitored by microdialysis of unrestrained conscious rats.Research communications in chemical pathology and pharmacology, 79 3
V. Ruban (1993)
Determination of dopamine and its metabolites in microdialysates by capillary liquid chromatography with electrochemical detection.Journal of chromatography, 619 1
T. Aasmundstad, J. Mørland, R. Paulsen (1995)
Distribution of morphine 6-glucuronide and morphine across the blood-brain barrier in awake, freely moving rats investigated by in vivo microdialysis sampling.The Journal of pharmacology and experimental therapeutics, 275 1
G. Felländer, J. Nordenström, U. Ungerstedt, P. Arner, J. Bolinder (1994)
Influence of operation on glucose metabolism and lipolysis in human adipose tissue: a microdialysis study.The European journal of surgery = Acta chirurgica, 160 2
P. Bungay, P. Morrison, R. Dedrick (1990)
Steady-state theory for quantitative microdialysis of solutes and water in vivo and in vitro.Life sciences, 46 2
P. Mertes, B. Beck, Y. Jaboin, A. Stricker, J. Carteaux, G. Pinelli, K. Abassi, J. Villemot, C. Burlet, M. Boulangé (1993)
Microdialysis in the estimation of interstitial myocardial neuropeptide Y releaseRegulatory Peptides, 49
D. Deleu, S. Sarre, G. Ebinger, Y. Michotte (1991)
In vivo pharmacokinetics of levodopa and 3-O-methyldopa in muscleNaunyn-Schmiedeberg's Archives of Pharmacology, 344
L. Ståhle, S. Segersvärd, U. Ungerstedt (1990)
Theophylline concentration in the extracellular space of the rat brain: measurement by microdialysis and relation to behaviour.European journal of pharmacology, 185 2-3
D. Devineni, Andres Klein-Szanto, James Gallo (1996)
Uptake of temozolomide in a rat glioma model in the presence and absence of the angiogenesis inhibitor TNP-470.Cancer research, 56 9
Q. Wang, W. F. Elmquist (1994)
Amphotericin B plasma protein-binding studies using in vitro microdialysis and on-line HPLCPharm. Res., 10
U. Tossman, U. Ungerstedt (1986)
Microdialysis in the study of extracellular levels of amino acids in the rat brain.Acta physiologica Scandinavica, 128 1
M. Nakashima, N. Takeuchi, M. Hamada, K. Matsuyama, M. Ichikawa, S. Goto (1994)
In vivo microdialysis for pharmacokinetic investigations: a plasma protein binding study of valproate in rabbits.Biological & pharmaceutical bulletin, 17 12
D. Scott, C. Lunte (1993)
In Vivo Microdialysis Sampling in the Bile, Blood, and Liver of Rats to Study the Disposition of PhenolPharmaceutical Research, 10
E. Ljungdahl-Ståhle, E. Guzenda, D. Böttiger, B. Wahren, B. Oberg, L. Ståhle (1992)
Penetration of zidovudine and 3'-fluoro-3'-deoxythymidine into the brain, muscle tissue, and veins in cynomolgus monkeys: relation to antiviral actionAntimicrobial Agents and Chemotherapy, 36
J. Kehr (1993)
A survey on quantitative microdialysis: theoretical models and practical implicationsJournal of Neuroscience Methods, 48
Henrik Lorentzen, F. Kallehave, H. Kolmos, Ulrich Knigge, Jens Bülow, Finn Gottrup (1996)
Gentamicin concentrations in human subcutaneous tissueAntimicrobial Agents and Chemotherapy, 40
L. Ståhle, B. Öberg (1992)
Pharmacokinetics and distribution over the blood brain barrier of two acyclic guanosine analogs in rats, studied by microdialysisAntimicrobial Agents and Chemotherapy, 36
Nils Lindefors, Gustav Amberg, Urban Ungerstedt (1989)
Intracerebral microdialysis: I. Experimental studies of diffusion kinetics.Journal of pharmacological methods, 22 3
D. Allen, P. Crooks, R. Yokel (1992)
4-Trimethylammonium antipyrine: a quaternary ammonium nonradionuclide marker for blood-brain barrier integrity during in vivo microdialysis.Journal of pharmacological and toxicological methods, 28 3
M. Ekblom, M. Hammarlund-Udenaes, T. Lundqvist, P. Sjöberg (2004)
Potential Use of Microdialysis in Pharmacokinetics: A Protein Binding StudyPharmaceutical Research, 9
D. Allen, C. Orvig, R. Yokel (1995)
Evidence for energy-dependent transport of aluminum out of brain extracellular fluid.Toxicology, 98 1-3
M. Alonso, A. Bruelisauer, P. Misslin, M. Lemaire (1995)
Microdialysis Sampling to Determine the Pharmacokinetics of Unbound SDZ ICM 567 in Blood and Brain in Awake, Freely-Moving RatsPharmaceutical Research, 12
Terasaki Tetsuya, Deguchi Yoshiharu, Kasama Yuko, W. Pardridge, Tsuji Akira (1992)
Determination of in vivo steady-state unbound drug concentration in the brain interstitial fluid by microdialysisInternational Journal of Pharmaceutics, 81
J. Ben‐nun, D. Joyce, R. Cooper, S. Cringle, I. Constable (1989)
Pharmacokinetics of intravitreal injection. Assessment of a gentamicin model by ocular dialysis.Investigative ophthalmology & visual science, 30 6
D. Deleu, S. Sarre, Y. Michotte, G. Ebinger (1994)
Simultaneous in vivo microdialysis in plasma and skeletal muscle: a study of the pharmacokinetic properties of levodopa by noncompartmental analysis.Journal of pharmaceutical sciences, 83 1
Ada Herrera, D. Scott, C. Lunte (1990)
Microdialysis Sampling for Determination of Plasma Protein Binding of DrugsPharmaceutical Research, 7
N. Kurata, M. Inagaki, M. Iwase, Y. Nishimura, Y. Kiuchi, Y. Yamazaki, S. Kobayashi, K. Oguchi, E. Uchida, H. Yasuhara (1995)
Pharmacokinetic study of trimethadione and its metabolite in blood, liver and brain by microdialysis in conscious, unrestrained rats.Research communications in molecular pathology and pharmacology, 89 1
K. Dykstra, J. Hsiao, P. Morrison, P. Bungay, I. Mefford, Melinda Scully, R. Dedrick (1992)
Quantitative Examination of Tissue Concentration Profiles Associated with MicrodialysisJournal of Neurochemistry, 58
M. Ekblom, M. Gårdmark, M. Hammarlund-Udenaes (1992)
Estimation of unbound concentrations of morphine from microdialysate concentrations by use of nonlinear regression analysis in vivo and in vitro during steady state conditions.Life sciences, 51 6
K. Steele, C. Lunte (1995)
Microdialysis sampling coupled to on-line microbore liquid chromatography for pharmacokinetic studies.Journal of pharmaceutical and biomedical analysis, 13 2
C. Marsden, I. Macdonald, M. Joseph, D. Perrett (1990)
Electrochemical detection, HPLC and in vivo monitoring in the biosciencesJournal of Neuroscience Methods, 34
Peter Arner, Jens Bülow (1993)
Assessment of adipose tissue metabolism in man: comparison of Fick and microdialysis techniques.Clinical science, 85 3
Simon Zhou, Hong Zuo, J. Stobaugh, C. Lunte, S. Lunte (1995)
Continuous in vivo monitoring of amino acid neurotransmitters by microdialysis sampling with on-line derivatization and capillary electrophoresis separation.Analytical chemistry, 67 3
B. Hogan, S. Lunte, J. Stobaugh, C. Lunte (1994)
On-line coupling of in vivo microdialysis sampling with capillary electrophoresis.Analytical chemistry, 66 5
L. Ståhle (1991)
The use of microdialysis in pharmacokinetics and pharmacodynamicsTechniques in The Behavioral and Neural Sciences, 7
J. Hsiao, Beth Ball, P. Morrison, I. Mefford, P. Bungay (1990)
Effects of Different Semipermeable Membranes on In Vitro and In Vivo Performance of Microdialysis ProbesJournal of Neurochemistry, 54
Markus Müller, Bettina v.Osten, R. Schmid, E. Piegler, Ingeborg Gerngroß (1995)
Theophylline kinetics in peripheral tissues in vivo in humansNaunyn-Schmiedeberg's Archives of Pharmacology, 352
B. Malhotra, M. Lemaire, R. Sawchuk (1994)
Investigation of the Distribution of EAB 515 to Cortical ECF and CSF in Freely Moving Rats Utilizing MicrodialysisPharmaceutical Research, 11
R. Scheyer, M. During, J. Hochholzer, D. Spencer, J. Cramer, R. Mattson (1994)
Phenytoin concentrations in the human brain: An in vivo microdialysis studyEpilepsy Research, 18
D. Scott, M. Bell, C. Lunte (1989)
Microdialysis-perfusion sampling for the investigation of phenol metabolism.Journal of pharmaceutical and biomedical analysis, 7 11
M. Hadwiger, M. Telting-Diaz, C. Lunte (1994)
Liquid chromatographic determination of tacrine and its metabolites in rat bile microdialysates.Journal of chromatography. B, Biomedical applications, 655 2
H. Stjernström, T. Karlsson, U. Ungerstedt, L. Hillered (2005)
Chemical monitoring of intensive care patients using intravenous microdialysisIntensive Care Medicine, 19
E. Lange, J. Vries, C. Zurcher, M. Danhof, A. Boer, D. Breimer (1995)
The Use of Intracerebral Microdialysis for the Determination of Pharmacokinetic Profiles of Anticancer Drugs in Tumor-Bearing Rat BrainPharmaceutical Research, 12
Markus Müller, R. Schmid, O. Wagner, Bettina Osten, H. Shayganfar, H. Eichler (1995)
In vivo characterization of transdermal drug transport by microdialysisJournal of Controlled Release, 37
R. Caprioli, S. Lin (1990)
On-line analysis of penicillin blood levels in the live rat by combined microdialysis/fast-atom bombardment mass spectrometry.Proceedings of the National Academy of Sciences of the United States of America, 87 1
L. Hegemann, C. Forstinger, B. Partsch, Irmgard Lagler, Sabine Krotz, K. Wolff (1995)
Microdialysis in cutaneous pharmacology: kinetic analysis of transdermally delivered nicotine.The Journal of investigative dermatology, 104 5
P. Lönnroth, P. Jansson, U. Smith (1987)
A microdialysis method allowing characterization of intercellular water space in humans.The American journal of physiology, 253 2 Pt 1
F. Matos, H. Rollema, A. Basbaum (1992)
Simultaneous Measurement of Extracellular Morphine and Serotonin in Brain Tissue and CSF by Microdialysis in Awake RatsJournal of Neurochemistry, 58
E. Hagstrom, P. Arner, P. Engfeldt, S. Rossner, J. Bolinder (1990)
In vivo subcutaneous glucose kinetics after glucose ingestion in obesity and fastingScand. J. Clin. Lab. Invest., 50
L. Stahle (1993)
Microdialysis in pharmacokineticsEur. J. Drug Metab Pharmacok., 18
Markus Müller, O. Haag, T. Burgdorff, A. Georgopoulos, W. Weninger, Burkhard Jansen, Gerold Stanek, H. Pehamberger, E. Agneter, Hans-Georg Eichler (1996)
Characterization of peripheral-compartment kinetics of antibiotics by in vivo microdialysis in humansAntimicrobial Agents and Chemotherapy, 40
Michael Morgan, D. Singhal, Bradley Anderson (1996)
Quantitative assessment of blood-brain barrier damage during microdialysis.The Journal of pharmacology and experimental therapeutics, 277 2
Yanfeng Wang, Devin Welty (1996)
The Simultaneous Estimation of the Influx and Efflux Blood-Brain Barrier Permeabilities of Gabapentin Using a Microdialysis-Pharmacokinetic ApproachPharmaceutical Research, 13
C. Anderson, T. Andersson, K. Wårdell (1994)
Changes in skin circulation after insertion of a microdialysis probe visualized by laser Doppler perfusion imaging.The Journal of investigative dermatology, 102 5
E. Eisenberg, P. Conzentino, W. Eickhoff, K. Cundy (1993)
Pharmacokinetic measurement of drugs in lung epithelial lining fluid by microdialysis: aminoglycoside antibiotics in rat bronchi.Journal of pharmacological and toxicological methods, 29 2
H. Benveniste, J. Drejer, A. Schousboe, N. Diemer (1987)
Regional Cerebral Glucose Phosphorylation and Blood Flow After Insertion of a Microdialysis Fiber Through the Dorsal Hippocampus in the RatJournal of Neurochemistry, 49
J. Ault, C. Lunte, N. Meltzer, C. Riley (1992)
Microdialysis Sampling for the Investigation of Dermal Drug TransportPharmaceutical Research, 9
D. Scott, L. Sørensen, C. Lunte (1990)
In vivo microdialysis sampling coupled to liquid chromatography for the study of acetaminophen metabolism.Journal of chromatography, 506
P. Morrison, P. Bungay, J. Hsiao, Beth Ball, I. Mefford, R. Dedrick (1991)
Quantitative Microdialysis: Analysis of Transients and Application to Pharmacokinetics in BrainJournal of Neurochemistry, 57
J. Henriksson, H. Rosdahl, T. Fuchi, Y. Oshida, U. Ungerstedt (1990)
Muscle and Motility
J. Ben-Nun, R. L. Cooper, S. J. Cringle, I. J. Constable (1988)
A new technique for in vivo pharmacokinetic measurementsArch. Ophthamol., 106
R. K. Dubey, C. V. McAllister, M. Inoue, G. R. Wilkinson (1989)
Plasma binding and transport of diazepam across the blood-brain barrierJ. Clin. Invest., 84
A. Kuzmin, O. Tskitishvili, L. Serebryakova, V. Kapelko, I. Majorova, O. Medvedev (1995)
Allopurinol: Kinetics, Inhibition of Xanthine Oxidase Activity, and Protective Effect in Ischemic‐Reperfused Canine Heart as Studied by Cardiac MicrodialysisJournal of Cardiovascular Pharmacology, 25
J. Boer, H. Plijtergroendijk, J. Korf (1993)
Microdialysis probe for transcutaneous monitoring of ethanol and glucose in humans.Journal of applied physiology, 75 6
P. Lönnroth, J. Carlsten, L. Johnson, U. Smith (1991)
Measurements by microdialysis of free tissue concentrations of propranolol.Journal of chromatography, 568 2
K. Belle, T. Dzeka, S. Sarre, G. Ebinger, Y. Michotte (1993)
In vitro and in vivo microdialysis calibration for the measurement of carbamazepine and its metabolites in rat brain tissue using the internal reference techniqueJournal of Neuroscience Methods, 49
V. Levin, H. Landahl, M. Freeman-Dove (1976)
The application of brain capillary permeability coefficient measurements to pathological conditions and the selection of agents which cross the blood-brain barrierJournal of Pharmacokinetics and Biopharmaceutics, 4
L. Ståhle (1991)
Drug distribution studies with microdialysis: I. Tissue dependent difference in recovery between caffeine and theophylline.Life sciences, 49 24
Dr. Ståhle (2006)
Pharmacokinetic estimations from microdialysis dataEuropean Journal of Clinical Pharmacology, 43
Kelly Dix, Kelly Dix, L. Deterding, L. Burka, K. Tomer (1994)
Tris(2-chloroethyl) phosphate pharmacokinetics in the Fischer 344 rat: a comparison of conventional methods and in vivo microdialysis coupled with tandem mass spectrometry.Journal of pharmaceutical sciences, 83 11
G. Metry, P. Attman, P. Lönnroth, S. Beshara, M. Aurell (1993)
Urea kinetics during hemodialysis measured by microdialysis--a novel technique.Kidney international, 44 3
Hua Yang, W. Elmquist (1996)
The Binding of Cyclosporin A to Human Plasma: An in Vitro Microdialysis StudyPharmaceutical Research, 13
P. Jansson, J. Fowelin, Henning Schenck, U. Smith, P. Lönnroth (1993)
Measurement by Microdialysis of the Insulin Concentration in Subcutaneous Interstitial Fluid: Importance of the Endothelial Barrier for InsulinDiabetes, 42
A. Quellec, S. Dupin, A. Tufenkji, P. Genissel, G. Houin (1994)
Microdialysis: An Alternative for in Vitro and in Vivo Protein Binding StudiesPharmaceutical Research, 11
L. Parsons, A. Smith, J. Justice (1991)
The in vivo microdialysis recovery of dopamine is altered independently of basal level by 6-hydroxydopamine lesions to the nucleus accumbensJournal of Neuroscience Methods, 40
T. Robinson, D. Camp (1991)
The feasibility of repeated microdialysis for within-subjects design experiments : studies on the mesostriatal dopamine systemTechniques in The Behavioral and Neural Sciences, 7
H. Benveniste (1989)
Brain microdialysisJ. Neurochem., 52
C. Anderson, T. Andersson, M. Molander (1991)
Ethanol absorption across human skin measured by in vivo microdialysis technique.Acta dermato-venereologica, 71 5
J. Georgieva, J. Luthman, B. Mohringe, O. Magnusson (1993)
Tissue and microdialysate changes after repeated and permanent probe implantation in the striatum of freely moving ratsBrain Research Bulletin, 31
J. Ault, C. Riley, N. Meltzer, C. Lunte (1994)
Dermal Microdialysis Sampling in VivoPharmaceutical Research, 11
Yuji Sato, S. Shibanoki, M. Sugahara, K. Ishikawa (1994)
Measurement and pharmacokinetic analysis of imipramine and its metabolite by brain microdialysisBritish Journal of Pharmacology, 112
P. Hughes, R. Krishnamoorthy, A. Mitra (1996)
Vitreous disposition of two acycloguanosine antivirals in the albino and pigmented rabbit models: a novel ocular microdialysis technique.Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 12 2
Per-Anders Jansson, Thiemo Veneman, N. Nurjhan, John Gerich (1994)
An improved method to calculate adipose tissue interstitial substrate recovery for microdialysis studies.Life sciences, 54 21
K. Belle, S. Sarre, G. Ebinger, Y. Michotte (1995)
Brain, liver and blood distribution kinetics of carbamazepine and its metabolic interaction with clomipramine in rats: a quantitative microdialysis study.The Journal of pharmacology and experimental therapeutics, 272 3
M. J. During (1991)
Microdialysis in the Neurosciences. Techniques in the Behavioral and Neural Sciences
P. Kissinger, R. Shoup (1990)
Optimization of LC apparatus for determinations in neurochemistry with an emphasis on microdialysis samplesJournal of Neuroscience Methods, 34
L. Ståhle, S. Segersvärd, U. Ungerstedt (1991)
Drug distribution studies with microdialysis. II. Caffeine and theophylline in blood, brain and other tissues in rats.Life sciences, 49 24
W. F. Elmquist, H. Yang (1993)
In vitro microdialysis study of the thermodynamics of cyclosporin A binding to components of human plasmaCurr. Sep., 12
S. Sarre, K. Belle, I. Smolders, G. Krieken, Y. Michotte (1992)
The use of microdialysis for the determination of plasma protein binding of drugs.Journal of pharmaceutical and biomedical analysis, 10 10-12
M. Telting-Diaz, C. Lunte (2004)
Distribution of Tacrine Across the Blood–Brain Barrier in Awake, Freely Moving Rats Using in Vivo Microdialysis SamplingPharmaceutical Research, 10
B. Blöchl‐Daum, M. Müller, V. Meisinger, Hans-Georg Eichler, A. Fassolt, H. Pehamberger (1996)
Measurement of extracellular fluid carboplatin kinetics in melanoma metastases with microdialysis.British Journal of Cancer, 73
T. Mindermann, H. Landolt, W. Zimmerli, Z. Rajacic, O. Gratzl (1993)
Penetration of rifampicin into the brain tissue and cerebral extracellular space of rats.The Journal of antimicrobial chemotherapy, 31 5
Atsushi Sakata, I. Tamai, K. Kawazu, Y. Deguchi, T. Ohnishi, A. Saheki, A. Tsuji (1994)
In vivo evidence for ATP-dependent and P-glycoprotein-mediated transport of cyclosporin A at the blood-brain barrier.Biochemical pharmacology, 48 10
E. Lange, M. Hesselink, M. Danhof, A. Boer, D. Breimer (2004)
The Use of Intracerebral Microdialysis to Determine Changes in Blood-Brain Barrier Transport CharacteristicsPharmaceutical Research, 12
P. Evrard, J. Cumps, R. Verbeeck (2004)
Concentration-Dependent Plasma Protein Binding of Flurbiprofen in the Rat: An in Vivo Microdialysis StudyPharmaceutical Research, 13
Z. Chen, R. Steger (1993)
Plasma microdialysis. A technique for continuous plasma sampling in freely moving rats.Journal of pharmacological and toxicological methods, 29 2
C. Sauernheimer, K. Williams, K. Brune, G. Geisslinger (1994)
Application of microdialysis to the pharmacokinetics of analgesics: problems with reduction of dialysis efficiency in vivo.Journal of pharmacological and toxicological methods, 32 3
O. Major, T. Shdanova, L. Duffek, Z. Nagy (1990)
Continuous monitoring of blood-brain barrier opening to Cr51-EDTA by microdialysis following probe injury.Acta neurochirurgica. Supplementum, 51
P. Gamache, E. Ryan, C. Svendsen, K. Murayama, Ian Acworth (1993)
Simultaneous measurement of monoamines, metabolites and amino acids in brain tissue and microdialysis perfusates.Journal of chromatography, 614 2
E. Hagström, P. Arner, P. Engfeldt, S. Rössner, J. Bolinder (1990)
In vivo subcutaneous adipose tissue glucose kinetics after glucose ingestion in obesity and fasting.Scandinavian journal of clinical and laboratory investigation, 50 2
J. Yergey, M. Heyes (1990)
Brain Eicosanoid Formation following Acute Penetration Injury as Studied by in vivo MicrodialysisJournal of Cerebral Blood Flow & Metabolism, 10
J. Wolf, L. Duin, J. Korf (1991)
The Extracellular Concentration of the Anti‐epileptic Drug Valproate in the Rat Brain as Determined with Microdialysis and an Automated HPLC ProcedureJournal of Pharmacy and Pharmacology, 43
M. During (1991)
In vivo neurochemistry of the conscious human brain: intrahippocampal microdialysis in epilepsyTechniques in The Behavioral and Neural Sciences, 7
R. Takahashi, M. Hagiwara, M. Watabe, R. Kan, Y. Takahashi (1993)
Carbamazepine and carbamazepine-10, 11-epoxide concentrations in rat brain and blood evaluated by in vivo microdialysisJap. J. Psych. Neuro., 47
P. Golden, K. Brouwer, G. Pollack (1993)
Assessment of Valproic Acid Serum–Cerebrospinal Fluid Transport by MicrodialysisPharmaceutical Research, 10
M. Linhares, P. Kissinger (1993)
Pharmacokinetic Monitoring in Subcutaneous Tissue Using in Vivo Capillary Ultrafiltration ProbesPharmaceutical Research, 10
R. Yokel, V. Lidums, U. Ungerstedt (1991)
Aluminum mobilization by desferrioxamine assessed by microdialysis of the blood, liver and brain.Toxicology, 66 3
R Dubey, C McAllister, M. Inoue, G Wilkinson (1989)
Plasma binding and transport of diazepam across the blood-brain barrier. No evidence for in vivo enhanced dissociation.The Journal of clinical investigation, 84 4
D. Welty, G. Schielke, M. Vartanian, C. Taylor (1993)
Gabapentin anticonvulsant action in rats: disequilibrium with peak drug concentrations in plasma and brain microdialysateEpilepsy Research, 16
C. Nicholson, J. Phillips (1981)
Ion diffusion modified by tortuosity and volume fraction in the extracellular microenvironment of the rat cerebellum.The Journal of Physiology, 321
B. Malhotra, M. Lemaire, J. Brouillard, R. Sawchuk (1996)
High-performance liquid chromatographic analysis of (S)-α-amino-5-phosphonomethyl[1,1'-biphenyl]-3-propanoic acid (EAB 515) in brain and blood microdialysate (on-line) and in plasma ultrafiltrate of freely moving ratsJournal of Chromatography B: Biomedical Sciences and Applications, 679
M. Müller, R. Schmid, A. Georgopoulos, A. Buxbaum, Carola Wasicek, H. Eichler (1995)
Application of microdialysis to clinical pharmacokinetics in humansClinical Pharmacology & Therapeutics, 57
P. Michelsen, G. Pettersson (1994)
An automated liquid chromatography/mass spectrometry system coupled on-line with microdialysis for the in vivo analysis of contrast agents.Rapid communications in mass spectrometry : RCM, 8 7
S. Menacherry, Walt. Hubert, J. Justice (1992)
In vivo calibration of microdialysis probes for exogenous compounds.Analytical chemistry, 64 6
Y. Takada, M. Yoshida, M. Sakairi, H. Koizumi (1995)
Detection of gamma-aminobutyric acid in a living rat brain using in vivo microdialysis-capillary electrophoresis/mass spectrometry.Rapid communications in mass spectrometry : RCM, 9 10
L. Ståhle, P. Arner, U. Ungerstedt (1991)
Drug distribution studies with microdialysis. III: Extracellular concentration of caffeine in adipose tissue in man.Life sciences, 49 24
I. Westergren, B. Nyström, A. Hamberger, B. Johansson (1995)
Intracerebral Dialysis and the Blood‐Brain BarrierJournal of Neurochemistry, 64
L. Ståhle, S. Segersvärd, U. Ungerstedt (1991)
A comparison between three methods for estimation of extracellular concentrations of exogenous and endogenous compounds by microdialysis.Journal of pharmacological methods, 25 1
L. Deterding, Kelly Dix, L. Burka, K. Tomer (1992)
On-line coupling of in vivo microdialysis with tandem mass spectrometry.Analytical chemistry, 64 21
T. Terasaki, Y. Deguchi, Hitoshi Sato, K. Hirai, A. Tsuji (1991)
In Vivo Transport of a Dynorphin-like Analgesic Peptide, E-2078, Through the Blood–Brain Barrier: An Application of Brain MicrodialysisPharmaceutical Research, 8
H. Benveniste, P. Hüttemeier (1990)
Microdialysis—Theory and applicationProgress in Neurobiology, 35
N. Stempels, M. Tassignon, S. Sarre (1993)
A removable ocular microdialysis system for measuring vitreous biogenic aminesGraefe's Archive for Clinical and Experimental Ophthalmology, 231
T. Nakazono, T. Murakami, S. Sakai, Y. Higashi, N. Yata (1992)
Application of microdialysis for study of caffeine distribution into brain and cerebrospinal fluid in rats.Chemical & pharmaceutical bulletin, 40 9
N. Stempels, M. Tassignon, S. Sarre, J. Nguyen‐Legros (1994)
Microdialysis measurement of catecholamines in rabbit vitreous after retinal laser photocoagulation.Experimental eye research, 59 4
E. Lange, M. Bouw, J. Mandema, M. Danhof, A. Boer, D. Breimer (1995)
Application of intracerebral microdialysis to study regional distribution kinetics of drugs in rat brainBritish Journal of Pharmacology, 116
K. Matsuyama, M. Nakashima, Yukiko Nakaboh, M. Ichikawa, T. Yano, S. Satoh (1994)
Application of in Vivo Microdialysis to Transdermal Absorption of Methotrexate in RatsPharmaceutical Research, 11
M. Ehrnebo (1986)
Drug-protein binding
K. Matsuyama, M. Nakashima, M. Ichikawa, T. Yano, S. Satoh, S. Goto (1994)
In vivo microdialysis for the transdermal absorption of valproate in rats.Biological & pharmaceutical bulletin, 17 10
M. Barjavel, J. Scherrmann, H. Bhargava (1995)
Relationship between morphine analgesia and cortical extracellular fluid levels of morphine and its metabolites in the rat: a microdialysis studyBritish Journal of Pharmacology, 116
M. Miller, R. Geary (1991)
RIA-linked microdialysis sampling in the awake rat: application to free-drug pharmacokinetics of hydrocortisone.Journal of pharmaceutical and biomedical analysis, 9 10-12
P. Evrard, G. Deridder, R. Verbeeck (2004)
Intravenous Microdialysis in the Mouse and the Rat: Development and Pharmacokinetic Application of a New ProbePharmaceutical Research, 13
D. Deleu, S. Sarre, G. Ebinger, Y. Michotte (1991)
In vivo pharmacokinetics of levodopa and 3-O-methyldopa in muscle. A microdialysis studyNaunyn-Schmied. Arch Pharmacol., 344
L. Parsons, J. Justice (1994)
Quantitative approaches to in vivo brain microdialysis.Critical reviews in neurobiology, 8 3
R. Yokel, R. Yokel, Vitauts Lidums, Patrick McNamara, Patrick McNamara, Urban Ungerstedt (1991)
Aluminum distribution into brain and liver of rats and rabbits following intravenous aluminum lactate or citrate: a microdialysis study.Toxicology and applied pharmacology, 107 1
L. Simonsen, J. Bülow, J. Madsen (1994)
Adipose tissue metabolism in humans determined by vein catheterization and microdialysis techniques.The American journal of physiology, 266 3 Pt 1
S. Menacherry, J. Justice (1990)
In vivo microdialysis and thermospray tandem mass spectrometry of the dopamine uptake blocker 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)-piper azine (GBR-12909).Analytical chemistry, 62 6
J. Waga, B. Ehinger (2004)
Passage of drugs through different intraocular microdialysis membranesGraefe's Archive for Clinical and Experimental Ophthalmology, 233
Luis Granero, Marti Santiago, J. Cano, Alberto Machado, JOSÉ-ESTEBAN Peris (1995)
Analysis of ceftriaxone and ceftazidime distribution in cerebrospinal fluid of and cerebral extracellular space in awake rats by in vivo microdialysisAntimicrobial Agents and Chemotherapy, 39
D. Devineni, A. Klein-Szanto, J. Gallo (1996)
In vivo microdialysis to characterize drug transport in brain tumors: analysis of methotrexate uptake in rat glioma-2 (RG-2)-Bearing ratsCancer Chemotherapy and Pharmacology, 38
Y. Wang, R. Sawchuk (1995)
Zidovudine transport in the rabbit brain during intravenous and intracerebroventricular infusion.Journal of pharmaceutical sciences, 84 7
L. Ståhle (1993)
Zero and first moment area estimation from microdialysis data.European journal of clinical pharmacology, 45 5
K. Hargreaves, A. Costello (1990)
Glucocorticoids suppress levels of immunoreactive bradykinin in inflamed tissue as evaluated by microdialysis probesClinical Pharmacology & Therapeutics, 48
Y. Deguchi, Kazimori Inabe, K. Tomiyasu, K. Nozawa, S. Yamada, R. Kimura (1995)
Study on Brain Interstitial Fluid Distribution and Blood-Brain Barrier Transport of Baclofen in Rats by MicrodialysisPharmaceutical Research, 12
Yanfeng Wang, S. Wong, R. Sawchuk (1993)
Microdialysis Calibration Using Retrodialysis and Zero-Net Flux: Application to a Study of the Distribution of Zidovudine to Rabbit Cerebrospinal Fluid and ThalamusPharmaceutical Research, 10
S. Téllez, N. Forges, A. Roussin, L. Hernandez (1992)
Coupling of microdialysis with capillary electrophoresis: a new approach to the study of drug transfer between two compartments of the body in freely moving rats.Journal of chromatography, 581 2
Y. Deguchi, T. Terasaki, S. Kawasaki, A. Tsuji (1991)
Muscle microdialysis as a model study to relate the drug concentration in tissue interstitial fluid and dialysate.Journal of pharmacobio-dynamics, 14 8
H. Benveniste, A. Hansen, N. Ottosen (1989)
Determination of Brain Interstitial Concentrations by MicrodialysisJournal of Neurochemistry, 52
R. Yokel, D. Allen, D. Burgio, P. McNamara (1992)
Antipyrine as a dialyzable reference to correct differences in efficiency among and within sampling devices during in vivo microdialysis.Journal of pharmacological and toxicological methods, 27 3
I. Jacobson, M. Sandberg, A. Hamberger (1985)
Mass transfer in brain dialysis devices—a new method for the estimation of extracellular amino acids concentrationJournal of Neuroscience Methods, 15
Hua Yang, Qin Wang, William Elmquist (1996)
Fluconazole Distribution to the Brain: A Crossover Study in Freely-moving Rats Using In Vivo MicrodialysisPharmaceutical Research, 13
M. Linhares, P. Kissinger (1992)
In vivo sampling using loop microdialysis probes coupled to a liquid chromatograph.Journal of chromatography, 578 2
M. Fontaine, Q. Wang, H. Yang, W. F. Elmquist (1995)
Effect of interleukin-2 on the blood brain barrier: An in vivo microdialysis studyPharm. Res., 12
M. Telting-Diaz, D. Scott, C. Lunte (1992)
Intravenous microdialysis sampling in awake, freely-moving rats.Analytical chemistry, 64 7
D. Scott, L. Sorenson, Karla Steele, D. Puckett, C. Lunte (1991)
In Vivo Microdialysis Sampling for Pharmacokinetic InvestigationsPharmaceutical Research, 8
D. Burgio, M. Gosland, P. McNamara (1996)
Modulation effects of cyclosporine on etoposide pharmacokinetics and CNS distribution in the rat utilizing microdialysis.Biochemical pharmacology, 51 7
E. Lange, M. Danhof, A. Boer, D. Breimer (1994)
Critical factors of intracerebral microdialysis as a technique to determined the pharmacokinetics of drugs in rat brainBrain Research, 666
S. Wong, K. Belle, R. Sawchuk (1993)
Distributional transport kinetics of zidovudine between plasma and brain extracellular fluid/cerebrospinal fluid in the rabbit: investigation of the inhibitory effect of probenecid utilizing microdialysis.The Journal of pharmacology and experimental therapeutics, 264 2
J. Waga, A. Ohta, B. Ehinger (1991)
Intraocular microdialysis with permanently implanted probes in rabbitActa Ophthalmologica, 69
S. Wong, Yanfeng Wang, R. Sawchuk (1992)
Analysis of Zidovudine Distribution to Specific Regions in Rabbit Brain Using MicrodialysisPharmaceutical Research, 9
U. Warpman, X Zhang, A. Nordberg (1996)
Effect of tacrine on in vivo release of dopamine and its metabolites in the striatum of freely moving rats.The Journal of pharmacology and experimental therapeutics, 277 2
Qin Wang, Hua Yang, Donald Miller, William Elmquist (1995)
Effect of the p-glycoprotein inhibitor, cyclosporin A, on the distribution of rhodamine-123 to the brain: an in vivo microdialysis study in freely moving rats.Biochemical and biophysical research communications, 211 3
R. Scheyer, M. During, D. Spencer, J. Cramer, R. Mattson (1994)
Measurement of carbamazepine and carbamazepine epoxide in the human brain using in vivo microdialysisNeurology, 44
J. Ben‐nun, R. Cooper, S. Cringle, I. Constable (1988)
Ocular dialysis. A new technique for in vivo intraocular pharmacokinetic measurements.Archives of ophthalmology, 106 2
P. Arner, J. Bolinder (1991)
Microdialysis of adipose tissueJournal of Internal Medicine, 230
H. Benveniste, N. Diemer (2004)
Cellular reactions to implantation of a microdialysis tube in the rat hippocampusActa Neuropathologica, 74
A. Chen, C. Lunte (1995)
Microdialysis sampling coupled on-line to fast microbore liquid chromatography.Journal of chromatography. A, 691 1-2
L. Ståhle, C. Alm, B. Ekquist, B. Lundquist, T. Tomson (1996)
Monitoring free extracellular valproic acid by microdialysis in epileptic patients.Therapeutic drug monitoring, 18 1
M. Linhares, P. Kissinger (1994)
Pharmacokinetic studies using microdialysis probes in subcutaneous tissue: effects of the co-administration of ethanol and acetaminophen.Journal of pharmaceutical and biomedical analysis, 12 5
P. Ekstrøm, A. Andersen, D. Warren, K. Giercksky, L. Slørdal (1994)
Evaluation of methotrexate tissue exposure by in situ microdialysis in a rat modelCancer Chemotherapy and Pharmacology, 34
P. Patsalos, W. Abed, M. Alavijeh, M. O’Connell (1995)
The use of microdialysis for the study of drug kinetics: some methodological considerations illustrated with antipyrine in rat frontal cortexBritish Journal of Pharmacology, 115
Fu-Chou Cheng, Jon-Son Kuo (1995)
High-performance liquid chromatographic analysis with electrochemical detection of biogenic amines using microbore columns.Journal of chromatography. B, Biomedical applications, 665 1
D. Camp, T. Robinson (1992)
On the Use of Multiple Probe Insertions at the Same Site for Repeated Intracerebral Microdialysis Experiments in the Nigrostriatal Dopamine System of RatsJournal of Neurochemistry, 58
M. Hedaya, R. Sawchuk (1989)
Effect of probenecid on the renal and nonrenal clearances of zidovudine and its distribution into cerebrospinal fluid in the rabbit.Journal of pharmaceutical sciences, 78 9
Gustav Amberg, Nils Lindefors (1989)
Intracerebral microdialysis: II. Mathematical studies of diffusion kinetics.Journal of pharmacological methods, 22 3
K. Dykstra, A. Arya, D. Arriola, P. Bungay, P. Morrison, R. Dedrick (1993)
Microdialysis study of zidovudine (AZT) transport in rat brain.The Journal of pharmacology and experimental therapeutics, 267 3
R. Kanthan, Ashfaq Shuaib, R. Griebel, Hiroki Miyashita (1995)
Intracerebral human microdialysis. In vivo study of an acute focal ischemic model of the human brain.Stroke, 26 5
R. Takahashi, M. Hagiwara, M. Watabe, R. Kan, Y. Takahashi (1993)
Carbamazepine and Carbamazepine‐10, 11‐Epoxide Concentrations in Rat Brain and Blood Evaluated by In Vivo MicrodialysisPsychiatry and Clinical Neurosciences, 47
Y. Wang, S. L. Wong, R. J. Sawchuk (1991)
Comparison of in vitro and in vivo calibration of microdialysis probes using retrodialysisCurr. Sep., 10
M. Müller, R. Schmid, M. Nieszpaur-Los, A. Fassolt, P. Lönnroth, P. Fasching, H. Eichler (1995)
Key metabolite kinetics in human skeletal muscle during ischaemia and reperfusion: measurement by microdialysisEuropean Journal of Clinical Investigation, 25
The objective of this review is to survey the recent literature regarding the various applications of microdialysis in pharmacokinetics. Microdialysis is a relatively new technique for sampling tissue extracellular fluid that is gaining popularity in pharmacokinetic and pharmacodynamic studies, both in experimental animals and humans. The first part of this review discusses various aspects of the technique with regard to its use in pharmacokinetic studies, such as: quantitation of the microdialysis probe relative recovery, interfacing the sampling technique with analytical instrumentation, and consideration of repeated procedures using the microdialysis probe. The remainder of the review is devoted to a survey of the recent literature concerning pharmacokinetic studies that apply the microdialysis sampling technique. While the majority of the pharmacokinetic studies that have utilized microdialysis have been done in the central nervous system, a growing number of applications are being found in a variety of peripheral tissue types, e.g. skin, muscle, adipose, eye, lung, liver, and blood, and these are considered as well. Given the rising interest in this technique, and the ongoing attempts to adapt it to pharmacokinetic studies, it is clear that microdialysis sampling will have an important place in studying drug disposition and metabolism.
Pharmaceutical Research – Springer Journals
Published: Sep 29, 2004
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.