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Pharmaceutical Chemistry Journal Vol. 37, No. 6, 2003 ANTIDOTE AND ANTIHYPOXANT ACTIVITY OF 1-ORGANYLIMIDAZOLE COMPLEXES WITH ZINC SALTS 1 1 1 1, 4 A. I. Skushnikova, E. S. Domnina, M. G. Voronkov, L. A. Tiunov, 2 3 V. A. Barinov, and V. V. Chumakov Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 37, No. 6, pp. 28 – 30, June, 2003. Original article submitted July 16, 2002. Zinc is a trace element playing a significant role in the 25 – 40°C, which yielded 2Vim ZnAsc (I), human organism. This element enters as an inorganic compo- 2Vim Zn(MPA) (II), 2Eim ZnAsc (III), and nent in some metalloenzyme systems, in particular, super- 2Eim Zn(MPA) (IV). The product compositions were con- oxide dismutase (a key antioxidant enzyme) and carbonate firmed by the results of elemental analyses and by the data of dehydrogenase (or carbonic anhydrase, a very important 1 IR, UV, and H NMR spectroscopy. agent involved in respiratory processes) [1 – 8]. The number In the IR absorption spectra, the complexation of Vim of zinc-containing drugs used in various fields of medicine is and Eim with zinc salts leads to a shortwave shift by continuously increasing [8]. –1 –1 10–20cm
Pharmaceutical Chemistry Journal – Springer Journals
Published: Oct 7, 2004
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