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- Publisher
- Springer Journals
- Copyright
- Copyright © 2004 by Plenum Publishing Corporation
- Subject
- Biomedicine; Biomedicine, general; Internal Medicine; Cell Biology; Pathology; Laboratory Medicine
- ISSN
- 0007-4888
- eISSN
- 1573-8221
- DOI
- 10.1023/B:BEBM.0000028131.91220.e1
- Publisher site
- See Article on Publisher Site
Abstract
Amino acid composition of a new Russian nephroprotective drug Nephrophyt (a complex mixture of dry plant extracts) was studied for the first time in order to validate its pharmacological effects in rats with mercuric chloride-induced nephropathy. The concentration of pyrrolidone amino acids and serine in this preparation was extremely high, which is uncommon for plant raw material. These data are in good correlation with pronounced nephroprotective effect and agree with published reports on pharmacological effects of individual amino acids and their metabolites. The prospects of the use of this preparation based on the data on its amino acid composition are discussed.
Journal
Bulletin of Experimental Biology and Medicine – Springer Journals
Published: Oct 18, 2004