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P. Shen, J. Guenther, L. Wanek, D. Morton (2000)
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Annals of Surgical Oncology, 7(8):550-551 Published by Lippincott Williams & Wilkins 9 2000 The Society of Surgical Oncology, Inc. Editorial Adjuvant Radiation After Lymph Node Dissection for Melanoma John A. Ridge, MD, PhD Surgical resection represents the mainstay of treatment widespread adoption of interferon-a, the Radiation Ther- for melanoma. Control of the tumor at the primary site is apy Oncology Group tried to compare node dissection usually achieved by wide excision. However, it is far alone with node dissection followed by radiation for more difficult to manage melanoma when the disease has patients with melanoma. The trial was terminated be- spread to regional lymph nodes. In many series the cause an insufficient number of patients were enrolled. regional recurrence rate after lymph node dissection ex- An ongoing Eastern Cooperative Oncology Group study ceeds 20%, and well-regarded institutions have reported (E3697) looks at adjuvant radiation after resection and regional failure rates as high as 50% for some types of incorporates treatment with interferon-a in both arms. patients. 1 Patients with melanoma metastatic to lymph Patients with cervical, axillary, and inguinal disease are nodes often die of cancer despite successful regional eligible. Presence of extracapsular tumor is a stratifica- treatment. Nevertheless,
Annals of Surgical Oncology – Springer Journals
Published: Oct 16, 2007
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