DOI 10.1007/s00198-007-0480-3 IS1 TECHNOLOGY INSIGHT: MEASURING BONE QUALITY AND BONE STRENGTH M. Bouxsein; Beth Israel Deaconess Medical Centre, Orthopaedic Biomechanics Laboratory, Harvard Medical School, USA Osteoporosis is defined as âa skeletal disorder characterized by compromised bone strength leading to an increased risk of fractureâ, thereby underscoring the key role of bone strength in understanding fracture risk. Whereas low bone mineral density (BMD) is among the strongest risk factors for fracture, a number of clinical investigations have demonstrated the limitations of BMD measurements in assessing fracture risk and monitoring the response to therapy. These observations have brought renewed attention to the array of factors that influence bone strength, and have motivated development of new approaches to assess these factors. The ability of a bone to resist fracture (or âwhole bone strengthâ) depends on the amount of bone (i.e., mass), the spatial distribution of the bone mass (i.e., shape and microarchitecture), and the intrinsic properties of the materials that comprise the bone. In particular, the assessment of bone macro- and micro-architecture, and prediction of whole bone strength using finite element analysis will be discussed. Finally, the concept and implications of using the ratio of applied loads to whole bone strength
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Abstracts of NOS Conference 2007
Follow Osteoporosis International
, Volume 18 (3)
Springer Journals – Nov 1, 2007
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