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S. Greenfield (1996)
Non-classical actions of cholinesterases: Role in cellular differentiation, tumorigenesis and Alzheimer's diseaseNeurochemistry International, 28
A. Boutillier, P. Kienlen-Campard, J. Loeffler (1999)
Depolarization regulates cyclin D1 degradation and neuronal apoptosis: a hypothesis about the role of the ubiquitin/proteasome signalling pathwayEuropean Journal of Neuroscience, 11
P. Kim, Young-Guen Kwon, Hun-taeg Chung, Young-Myeong Kim (2002)
Regulation of Caspases by Nitric OxideAnnals of the New York Academy of Sciences, 962
C. Ramassamy, D. Averill, U. Beffert, L. Théroux, S. Lussier‐Cacan, J. Cohn, Y. Christen, A. Schoofs, J. Davignon, J. Poirier (2000)
Oxidative Insults Are Associated with Apolipoprotein E Genotype in Alzheimer's Disease BrainNeurobiology of Disease, 7
Hsueh‐Meei Huang, Hsio‐Chung Ou, S. Hsieh (2000)
Antioxidants prevent amyloid peptide-induced apoptosis and alteration of calcium homeostasis in cultured cortical neurons.Life sciences, 66 19
(2001)
Peroxynitrite affects calcium influx through voltage-dependent calcium channels
E. Moya, I. Blagbrough (1996)
Efficient Syntheses of Polyamine and Polyamine Amide Voltage‐Sensitive Calcium Channel Blockers: FTX‐3.3 and sFTX‐3.3Journal of Pharmacy and Pharmacology, 48
K. Ferri, G. Kroemer (2001)
Organelle-specific initiation of cell death pathwaysNature Cell Biology, 3
B. Gähwiler (1984)
Development of the hippocampus in vitro: Cell types, synapses and receptorsNeuroscience, 11
S. Ohkuma, M. Katsura, A. Higo, K. Shirotani, A. Hara, Chihaya Tarumi, T. Ohgi (2001)
Peroxynitrite affects Ca2+ influx through voltage‐dependent calcium channelsJournal of Neurochemistry, 76
Philippe Sbgu&a, Jacques Wadiche, Kelly Dineley-Miller, John Dani, James Patrick (1993)
Molecular cloning, functional properties, and distribution of rat brain alpha 7: a nicotinic cation channel highly permeable to calcium, 13
S. Amoroso, A. D'Alessio, R. Sirabella, G. Renzo, L. Annunziato (2002)
Ca2+‐independent caspase‐3 but not Ca2+‐dependent caspase‐2 activation induced by oxidative stress leads to SH‐SY5Y human neuroblastoma cell apoptosisJournal of Neuroscience Research, 68
(2000)
N-Methyl-D-aspartate receptor mediated toxicity in nonneuronal cell lines: characterisation using fluorescent measures of cell viability and reactive oxygen species
Zs. Nagy, M. Esiri, A. Smith (1998)
The cell division cycle and the pathophysiology of Alzheimer's disease.Neuroscience, 87 4
J. Velázquez, M. Frantseva, P. Carlen (1997)
In Vitro Ischemia Promotes Glutamate-Mediated Free Radical Generation and Intracellular Calcium Accumulation in Hippocampal Pyramidal NeuronsThe Journal of Neuroscience, 17
K. Jellinger, C. Stadelmann (2001)
Problems of cell death in neurodegeneration and Alzheimer's Disease.Journal of Alzheimer's disease : JAD, 3 1
T. Day, S. Greenfield (2002)
A non-cholinergic, trophic action of acetylcholinesterase on hippocampal neurones in vitro: molecular mechanismsNeuroscience, 111
K. Marshall, R. Reiter, B. Poeggeler, O. Aruoma, B. Halliwell (1996)
Evaluation of the antioxidant activity of melatonin in vitro.Free radical biology & medicine, 21 3
B. Dickie, C. Holmes, S. Greenfield (1996)
Neurotoxic and neurotrophic effects of chronic N-methyl-d-aspartate exposure upon mesencephalic dopaminergic neurons in organotypic cultureNeuroscience, 72
Mauricio Montal (1998)
Mitochondria, glutamate neurotoxicity and the death cascade.Biochimica et biophysica acta, 1366 1-2
S. Greenfield, D. Vaux (2002)
Parkinson’s disease, Alzheimer’s disease and motor neurone disease: identifying a common mechanismNeuroscience, 113
J. Chan, M. Quik (1993)
A role for the nicotinic α-bungarotoxin receptor in neurite outgrowth in PC12 cellsNeuroscience, 56
A. Monji, Hideo Utsumi, T. Ueda, T. Imoto, I. Yoshida, S. Hashioka, K. Tashiro, N. Tashiro (2001)
The relationship between the aggregational state of the amyloid‐β peptides and free radical generation by the peptidesJournal of Neurochemistry, 77
J. Davies, J. Watkins (1982)
Actions of D and L forms of 2-amino-5-phosphonovalerate and 2-amino-4-phosphonobutyrate in the cat spinal cordBrain Research, 235
K. Ueda, S. Shinohara, T. Yagami, K. Asakura, K. Kawasaki (1997)
Amyloid β Protein Potentiates Ca2+ Influx Through L‐Type Voltage‐Sensitive Ca2+ Channels: A Possible Involvement of Free RadicalsJournal of Neurochemistry, 68
R. Reiter, D. Tan, J. Cabrera, D. D’Arpa, R. Sainz, J. Mayo, S. Ramos (1999)
The Oxidant/Antioxidant Network: Role of MelatoninNeurosignals, 8
Q. Guo, L. Sebastian, B. Sopher, M. Miller, C. Ware, G. Martin, M. Mattson (2008)
Increased vulnerability of hippocampal neurons from presenilin-1 mutant knock-in mice to amyloid beta-peptide toxicity: central roles of superoxide production and caspase activation.Journal of neurochemistry, 72 3
(1996)
Neurotoxic and neurotrophic effects of chronic NMDA exposure upon mesencephalic dopaminergic neurons in organotypic culture
B. Gähwiler (1981)
Organotypic monolayer cultures of nervous tissueJournal of Neuroscience Methods, 4
PC Pugh, D. Berg (1994)
Neuronal acetylcholine receptors that bind alpha-bungarotoxin mediate neurite retraction in a calcium-dependent manner, 14
Jonathan Moore, N. Rothwell, R. Gibson (2002)
Involvement of caspases and calpains in cerebrocortical neuronal cell death is stimulus‐dependentBritish Journal of Pharmacology, 135
J. Dykens (1994)
Isolated Cerebral and Cerebellar Mitochondria Produce Free Radicals when Exposed to Elevated Ca2+ and Na+: Implications for NeurodegenerationJournal of Neurochemistry, 63
(1997)
Oxidant injury on PC 12 cells — A possible model of calcium , , dysregulation , , in ageing : I . Selectivity of protection against oxidative stress
(1999)
Up - regulation of cylcin D 1 occurs in apoptosis of immature but not mature cerebellar granule neurons in cultures
(1996)
Non-classical actions of acetylcholinesterase: role in cellular differentiation, tumorigenesis and Alzheimer
T. Day, S. Greenfield (2004)
Bioactivity of a peptide derived from acetylcholinesterase in hippocampal organotypic culturesExperimental Brain Research, 155
J. Heng, D. Zurakowski, C. Vorwerk, C. Grosskreutz, E. Dreyer (1999)
Cation channel control of neurite morphology.Brain research. Developmental brain research, 113 1-2
M. Bucciantini, E. Giannoni, F. Chiti, F. Baroni, L. Formigli, J. Zurdo, N. Taddei, G. Ramponi, C. Dobson, M. Stefani (2002)
Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseasesNature, 416
S. Mironov, D. Richter (2000)
Hypoxic modulation of L-type Ca2+ channels in inspiratory brainstem neurones: Intracellular signalling pathways and metabotropic glutamate receptorsBrain Research, 869
D. DeGracia, Rita Kumar, C. Owen, G. Krause, B. White (2002)
Molecular Pathways of Protein Synthesis Inhibition during Brain Reperfusion: Implications for Neuronal Survival or DeathJournal of Cerebral Blood Flow & Metabolism, 22
J. Harada, M. Sugimoto (1999)
Activation of caspase-3 in β-amyloid-induced apoptosis of cultured rat cortical neuronsBrain Research, 842
David Park, E. Morris, L. Greene, H. Geller (1997)
G1/S Cell Cycle Blockers and Inhibitors of Cyclin-Dependent Kinases Suppress Camptothecin-Induced Neuronal ApoptosisThe Journal of Neuroscience, 17
Chunyi Zhang, Wanhua Shen, Guangyi Zhang (2002)
N-methyl-d-aspartate receptor and L-type voltage-gated Ca2+ channel antagonists suppress the release of cytochrome c and the expression of procaspase-3 in rat hippocampus after global brain ischemiaNeuroscience Letters, 328
Kazuhisa Sakai, Kazuhiko Suzuki, Shuuitsu Tanaka, T. Koike (1999)
Up‐regulation of cyclin D1 occurs in apoptosis of immature but not mature cerebellar granule neurons in cultureJournal of Neuroscience Research, 58
A. Raina, M. Monteiro, A. Mcshea, Mark Smith (1999)
The role of cell cycle‐mediated events in Alzheimer's diseaseInternational Journal of Experimental Pathology, 80
E. Okabe, C. Odajima, R. Taga, R. Kukreja, M. Hess, H. Ito (1988)
The effect of oxygen free radicals on calcium permeability and calcium loading at steady state in cardiac sarcoplasmic reticulum.Molecular pharmacology, 34 3
R. Lukas, L. Lucero, B. Buisson, J. Galzi, E. Puchacz, J. Fryer, J. Changeux, D. Bertrand (2001)
Neurotoxicity of channel mutations in heterologously expressed α7‐nicotinic acetylcholine receptorsEuropean Journal of Neuroscience, 13
M. Jacobson (1996)
Reactive oxygen species and programmed cell death.Trends in biochemical sciences, 21 3
(1990)
Regulation of brain
W. Catterall (2000)
Structure and regulation of voltage-gated Ca2+ channels.Annual review of cell and developmental biology, 16
(1994)
Isolated cerebral and cerebellar mitichondria produce free radicals when exposed to elevated calcium and sodium: implications for neruodegeneration
S. Sombati, D. Coulter, R. Delorenzo (1991)
Neurotoxic activation of glutamate receptors induces an extended neuronal depolarization in cultured hippocampal neuronsBrain Research, 566
T. Soderling, K. Fukunaga, D. Rich, Y. Fong, K. Smith, R. Colbran (1990)
Regulation of brain Ca2+/calmodulin-dependent protein kinase II.Advances in second messenger and phosphoprotein research, 24
C. Webb, S. Nedergaard, K. Giles, S. Greenfield (1996)
Involvement of the NMDA Receptor in a Non–cholinergic Action of Acetylcholinesterase in Guinea–pig Substantia Nigra Pars Compacta NeuronsEuropean Journal of Neuroscience, 8
B. Han, Daigen Xu, Junjeong Choi, Yongxin Han, S. Xanthoudakis, Sophie Roy, J. Tam, J. Vaillancourt, J. Colucci, R. Siman, A. Giroux, G. Robertson, R. Zamboni, D. Nicholson, D. Holtzman (2002)
Selective, Reversible Caspase-3 Inhibitor Is Neuroprotective and Reveals Distinct Pathways of Cell Death after Neonatal Hypoxic-ischemic Brain Injury*The Journal of Biological Chemistry, 277
S. Eimerl, M. Schramm (1994)
The Quantity of Calcium that Appears to Induce Neuronal DeathJournal of Neurochemistry, 62
A. Raina, Xiongwei Zhu, C. Rottkamp, M. Monteiro, A. Takeda, Mark Smith (2000)
Cyclin' toward dementiaJournal of Neuroscience Research, 61
Russel Reiter, Lei Tang, Joaquin Garcia, Antonio Muñoz-Hoyos (1997)
Pharmacological actions of melatonin in oxygen radical pathophysiology.Life sciences, 60 25
M. Appleyard (1994)
Non-cholinergic functions of acetylcholinesterase.Biochemical Society transactions, 22 3
N. Anegawa, Rodney Guttmann, E. Grant, René Anand, Jon Lindstrom, David Lynch (2000)
N-Methyl-D-aspartate receptor mediated toxicity in nonneuronal cell lines: characterization using fluorescent measures of cell viability and reactive oxygen species production.Brain research. Molecular brain research, 77 2
(1996)
Non - classical actions of acetylcholinesterase : role in cellular differentiation , tumorigenesis and Alzheimer , s disease : a critique
J. Joseph, J. Strain, N. Jimenez, D. Fisher (1997)
Oxidant Injury in PC12 Cells—A Possible Model of Calcium “Dysregulation” in Aging: I. Selectivity of Protection Against Oxidative StressJournal of Neurochemistry, 69
J. Coyle, P. Puttfarcken (1993)
Oxidative stress, glutamate, and neurodegenerative disorders.Science, 262 5134
W. Le, Luis Colom, W. Xie, R. Smith, M. Alexianu, Stanley Appel (1995)
Cell death induced by β-amyloid 1–40 in MES 23.5 hybrid clone: the role of nitric oxide and NMDA-gated channel activation leading to apoptosisBrain Research, 686
A. Giovanni, F. Wirtz-Brugger, Elizabeth Keramaris, R. Slack, David Park (1999)
Involvement of Cell Cycle Elements, Cyclin-dependent Kinases, pRb, and E2F·DP, in B-amyloid-induced Neuronal Death*The Journal of Biological Chemistry, 274
(1996)
A noncholinergic, trophic action of recombinant acetylcholinesterase on mid-brain dopaminergic neruons
(1990)
Regulation of brain Ca 2 + / calmodulin - dependent protein kinase II
(2000)
Structure and regulation of voltage-gated calcium channels
M. Grundman (2000)
Vitamin E and Alzheimer disease: the basis for additional clinical trials.The American journal of clinical nutrition, 71 2
S. Lei, Z. Pan, S. Aggarwal, Huei‐Sheng Chen, Jonathan Hartman, N. Sucher, S. Lipton (1992)
Effect of nitric oxide production on the redox modulatory site of the NMDA receptor-channel complexNeuron, 8
M. SPEDDING1, R. PAOLETTI2, R. Pao, J. Nueten, P. Zwieten (2005)
III. Classification of Calcium Channels and the Sites of Action of Drugs Modifying Channel Function
(2000)
Antioxidiants prevent amyloid peptide-induced apoptosis and alteration of calcium homeostasis in cultured cortical neurons
J. Clague, G. Langer (1994)
The pathogenesis of free radical-induced calcium leak in cultured rat cardiomyocytes.Journal of molecular and cellular cardiology, 26 1
Acetylcholinesterase (AChE) exhibits functions unrelated to the catalysis of acetylcholine (ACh) in particular during development. Although the underlying mechanism(s) is presently unknown, a candidate peptide fragment (AChE-peptide) has recently been identified, and been shown to induce a continuum of apoptotic and necrotic neuronal cell death in rat hippocampal organotypic cultures. The aim of this study was to trace the cell death pathway initiated by AChE-peptide. Using specific antagonists, it was possible to track a series of cellular events following application of 1 nM AChE-peptide: NMDA receptor activation, opening of the L-type voltage gated calcium channel, activation of calcium/calmodulin kinase II, generation of reactive oxygen species and caspase activation. Pharmacological interception at any stage of this cascade blocked the effect of 1 nM AChE-peptide on neurite retraction. Lactate dehydrogenase (LDH) release, a marker for cell lysis, was unaffected by 1 nM AChE-peptide. In contrast, cell death induced by 1 mM AChE-peptide, monitored as neurite retraction and increased LDH efflux, was not offset by any drug treatment. These data suggest that nanomolar concentrations of AChE-peptide exhibit pathophysiological activity via an apoptotic pathway that could play an important role in neuronal development and neurodegeneration.
Experimental Brain Research – Springer Journals
Published: Dec 1, 2003
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