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A mass fragmentographic method for the determination of chlorpromazine and two of its active metabolites in human plasma and CSF

A mass fragmentographic method for the determination of chlorpromazine and two of its active... 213 48 48 2 2 Gunnel Alfredsson Birgitta Wode-Helgodt Göran Sedvall Division of Neuropsychopharmacology, Department of Pharmacology Karolinska Institutet S-104 01 Stockholm the Department of Psychiatry St. Göran's Hospital S-112 81 Stockholm Sweden Abstract A mass fragmentographic method for the quantitation of chlorpromazine (CPZ), monodemethyl-chlorpromazine (nor 1 -CPZ), and 7-hydroxychlorpromazine (7-OH-CPZ) in plasma, cerebrospinal fluid, and tissues has been developed. The deuterated analogues of the compounds are used as internal standards. The high specificity was ascertained by multiple ion determination. The experimental error is below 10%. The sensitivity allows determination of sub ng quantities of CPZ per ml cerebrospinal fluid. The method has been applied to the analysis of drug concentrations in plasma and cerebrospinal fluid (CSF) of chlorpromazine-treated patients. The amount of CPZ in CSF was about 3% of the plasma level. The CPZ levels in plasma and CSF were significantly correlated. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychopharmacology Springer Journals

A mass fragmentographic method for the determination of chlorpromazine and two of its active metabolites in human plasma and CSF

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References (15)

Publisher
Springer Journals
Copyright
Copyright © 1976 by Springer-Verlag
Subject
Biomedicine; Pharmacology/Toxicology; Psychiatry
ISSN
0033-3158
eISSN
1432-2072
DOI
10.1007/BF00423250
Publisher site
See Article on Publisher Site

Abstract

213 48 48 2 2 Gunnel Alfredsson Birgitta Wode-Helgodt Göran Sedvall Division of Neuropsychopharmacology, Department of Pharmacology Karolinska Institutet S-104 01 Stockholm the Department of Psychiatry St. Göran's Hospital S-112 81 Stockholm Sweden Abstract A mass fragmentographic method for the quantitation of chlorpromazine (CPZ), monodemethyl-chlorpromazine (nor 1 -CPZ), and 7-hydroxychlorpromazine (7-OH-CPZ) in plasma, cerebrospinal fluid, and tissues has been developed. The deuterated analogues of the compounds are used as internal standards. The high specificity was ascertained by multiple ion determination. The experimental error is below 10%. The sensitivity allows determination of sub ng quantities of CPZ per ml cerebrospinal fluid. The method has been applied to the analysis of drug concentrations in plasma and cerebrospinal fluid (CSF) of chlorpromazine-treated patients. The amount of CPZ in CSF was about 3% of the plasma level. The CPZ levels in plasma and CSF were significantly correlated.

Journal

Psychopharmacology – Springer Journals

Published: Jan 1, 1976

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