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A behavioral and pharmacological analysis of some discriminable properties of d-LSD in rats

A behavioral and pharmacological analysis of some discriminable properties of d-LSD in rats 213 33 33 2 2 Oliver G. Cameron James B. Appel Departments of Psychiatry and Psychology and the Pritzker School of Medicine The University of Chicago 60637 Chicago Illinois USA University of South Carolina USA Abstract d-LSD was employed as a discriminative stimulus in a two-lever, freechoice procedure involving water reinforcement with rats. The results indicated that 1. doses of 0.02-0.04 mg/kg of d-LSD were at the “threshold” level of discriminability from no drug (saline), 2. 0.08 mg/kg was clearly discriminable from no drug, 3. the same dose of d-LSD (0.08 mg/kg) was also discriminable from d-amphetamine, and 4. subjects could probably discriminate, albeit weakly, between d-LSD and two other hallucinogens, mescaline and psilocybin. When a variety of drugs which were not used during training were tested during subsequent extinction sessions, it was found that most non-hallucinogenic drugs elicited responding predominantly on the non-drug lever; when hallucinogenic drugs were tested, preferences in general depended on dosage of the test drugs. It was also found that administration of PCPA, a drug which sensitizes rats to certain disruptive effects of LSD also sensitizes them to discriminative effects of the drug. Manipulations which might be expected to desensitize subjects (e.g., pretreatment with chlorpromazine, or with d-LSD itself in an “acute-tolerance” regimen), however, had no effect. Whether the discriminations of different drugs are due to qualitative or to quantitative (dosage) differences between drug states has proved to be a problem in the interpretation of drug discrimination experiments. It may, for example, contribute to the discrepancy observed between the present results and those of previous investigators who attempted to equate doses of LSD and mescaline. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychopharmacology Springer Journals

A behavioral and pharmacological analysis of some discriminable properties of d-LSD in rats

Cameron, Oliver; Appel, James
Psychopharmacology , Volume 33 (2) – Jun 1, 1973
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References (26)

Publisher
Springer Journals
Copyright
Copyright © 1973 by Springer-Verlag
Subject
Biomedicine; Pharmacology/Toxicology; Psychiatry
ISSN
0033-3158
eISSN
1432-2072
DOI
10.1007/BF00429082
Publisher site
See Article on Publisher Site

Abstract

213 33 33 2 2 Oliver G. Cameron James B. Appel Departments of Psychiatry and Psychology and the Pritzker School of Medicine The University of Chicago 60637 Chicago Illinois USA University of South Carolina USA Abstract d-LSD was employed as a discriminative stimulus in a two-lever, freechoice procedure involving water reinforcement with rats. The results indicated that 1. doses of 0.02-0.04 mg/kg of d-LSD were at the “threshold” level of discriminability from no drug (saline), 2. 0.08 mg/kg was clearly discriminable from no drug, 3. the same dose of d-LSD (0.08 mg/kg) was also discriminable from d-amphetamine, and 4. subjects could probably discriminate, albeit weakly, between d-LSD and two other hallucinogens, mescaline and psilocybin. When a variety of drugs which were not used during training were tested during subsequent extinction sessions, it was found that most non-hallucinogenic drugs elicited responding predominantly on the non-drug lever; when hallucinogenic drugs were tested, preferences in general depended on dosage of the test drugs. It was also found that administration of PCPA, a drug which sensitizes rats to certain disruptive effects of LSD also sensitizes them to discriminative effects of the drug. Manipulations which might be expected to desensitize subjects (e.g., pretreatment with chlorpromazine, or with d-LSD itself in an “acute-tolerance” regimen), however, had no effect. Whether the discriminations of different drugs are due to qualitative or to quantitative (dosage) differences between drug states has proved to be a problem in the interpretation of drug discrimination experiments. It may, for example, contribute to the discrepancy observed between the present results and those of previous investigators who attempted to equate doses of LSD and mescaline.

Journal

Psychopharmacology – Springer Journals

Published: Jun 1, 1973

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