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Use of a Direct Observational Measure in a Trial of Risperidone and Parent Training in Children with Pervasive Developmental Disorders

Use of a Direct Observational Measure in a Trial of Risperidone and Parent Training in Children with Pervasive Developmental Disorders A Structured Observational Analog Procedure (SOAP), an analogue measure of parent-child interactions, was used to assess treatment outcome in children with Autism Spectrum Disorder and serious behavior problems. It served as a secondary outcome measure in a 24-week, randomized trial of risperidone (MED; N = 49) versus risperidone plus parent training (COMB; n = 75) (ages 4–13 years). At 24-weeks, there was 28 % reduction in child inappropriate behavior during a Demand Condition ( p = .0002) and 12 % increase in compliance to parental requests ( p = .004) for the two treatment conditions combined. Parents displayed 64 % greater use of positive reinforcement ( p = .001) and fewer repeated requests for compliance ( p < .0001). In the analysis of covariance (ANCOVA), COMB parents used significantly more positive reinforcement ( p = .01) and fewer restrictive statements ( p < .05) than MED parents. The SOAP is sensitive to change in child and parent behavior as a function of risperidone alone and in combination with PMT and can serve as a valuable complement to parent and clinician-based measures. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Developmental and Physical Disabilities Springer Journals
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