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A genome-wide survey does not show the genetic distinctiveness of Basques

A genome-wide survey does not show the genetic distinctiveness of Basques Basques are a cultural isolate, and, according to mainly allele frequencies of classical polymorphisms, also a genetic isolate. We investigated the differentiation of Spanish Basques from the rest of Iberian populations by means of a dense, genome-wide SNP array. We found that F ST distances between Spanish Basques and other populations were similar to those between pairs of non-Basque populations. The same result is found in a PCA of individuals, showing a general distinction between Iberians and other South Europeans independently of being Basques. Pathogen-mediated natural selection may be responsible for the high differentiation previously reported for Basques at very specific genes such as ABO , RH , and HLA . Thus, Basques cannot be considered a genetic outlier under a general genome scope and interpretations on their origin may have to be revised. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Human Genetics Springer Journals
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