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of oligodendrocytes, but also extrinsic influences on oligodendrocytes. These data suggest that MBP-lacZ may be a useful marker in transgenic mouse models of remyelination . Toward a mouse model of transgenic ...
Two types of interventions to remyelinate the adult demyelinated central nervous system were investigated in heterozygous transgenic mice overexpressing the proteolipid protein gene. 1) A cocktail ...
the distribution of the sodium channel subunit Nav1.6 and the ultrastructure of axons after cuprizone‐induced demyelination in transgenic mice expressing GFP in oligodendroglial cells. Using this mouse model , we ...
of Olig2 can promote the differentiation of mouse NSCs into an oligodendrocytic cell lineage [17]. The remyelinating capacity of these NSC-derived OPCs was demonstrated in the cuprizone mouse model : feeding ...
harboring different GJB1 mutations, we injected the same vector in three different transgenic mouse models expressing on a Cx32 KO background representative Cx32 mutants that are either retained in the ER ...
and de novo overproduction of circulating biglycan in a transgenic mouse model elicits an innate immune response, highlighting the pro-inflammatory properties of biglycan.13,68 Biglycan impacts immune ...
regenerative processes. spinal cord injury, axon degeneration, remyelination , demyelination, transgenic model Introduction Spinal cord injury comprises many pathological events and leads to devastating deficits ...
], leading to microglial activation and oligodendrocyte death [9]. As PLP1 is fully conserved between mouse and human and no spontaneous duplication of Plp1 exists in animal models , several transgenic mice ...
inducible Cre recombinase transgenic mouse system. The loss of neuregulin 1 impaired remyelination after nerve crush, but did not affect Schwann cell proliferation associated with Wallerian degeneration ...
Abstract Evidence that cell transplants can improve recovery outcomes in spinal cord injury (SCI) models substantiates treatment strategies involving cell replacement for humans with SCI. Most pre ...
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