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for a series of phthalate monoesters and indicate the potential usefulness of primary rat hepatocyte cultures to screen compounds for peroxisome proliferation. STRUCTURE - ACTIVITY RELATIONSHIPS FOR INDUCTION ...
studies with a series of phthalate monoesters demonstrated structure activity differences in the induction of the specific peroxisomal marker KCN-insensitive palmitoyl-CoA oxidation and also of carnitine ...
of NFR, DTD, CAT, and peroxisome proliferation. Structural changes in the digestive gland of mussels also appear to be more responsive to chemical contaminant exposure than changes in enzyme activity ...
cell line that stably expresses PPARα, where the endogenous PPARα target genes peroxisomal bifunctional enzyme and peroxisomal 3-ketoacyl-CoA thiolase were activated up to ∼10–20-fold by PFOS and FOSA ...
also caused proliferation of peroxisomes in the rat and mouse proximal tubule. These results demonstrate a temporal relationship between induction of rat renal MFOs and proliferation of SER in specific ...
enzymes involved in β-oxidation, including acyl-CoA oxidase (AOX). The processing of AOX for its activation in peroxisomes was strongly inhibited in cells expressing a dominant negative form of pLon ...
, herbicides, and solvents. These structurally diverse chemicals induce a pleiotropic set of responses in rat and mouse liver, including hepatomegaly, induction of enzymes involved in fatty acid β-oxidation ...
). Peroxisomes were detected in the gradient by measuring catalase activity as a marker enzyme . To assess possible contamination by mitochondria, fumarase activity was used as a marker for these organelles ...
Abstract Peroxisomal fatty acid degradation in the yeast Saccharomyces cerevisiae requires an array of β-oxidation enzyme activities as well as a set of auxiliary activities to provide the β ...
of biological processes including lipid metabolism, inflammation, and cell growth. A group of structurally diverse compounds known as peroxisome proliferators also function, at least in part, by activating PPARα ...
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