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in cervical cancer growth inhibition. Silencing of HPV 18 Oncoproteins With RNA Interference Causes Growth Inhibition of Cervical Cancer Cells Jayanthi S. Lea, MD, Noriaki Sunaga, MD, Mitsuo Sato, MD, Geetha ...
in cervical cancer growth inhibition. Silencing of HPV 18 Oncoproteins With RNA Interference Causes Growth Inhibition of Cervical Cancer Cells Jayanthi S. Lea, MD, Noriaki Sunaga, MD, Mitsuo Sato, MD, Geetha ...
cervical carcinoma cells by RNA interference (RNAi) and performed a genomewide transcriptome analysis. Data from this array suggested that the expression of the “Lens Epithelial-Derived Growth Factor/p75 ...
by the viral oncogenes. Therefore, it is important to uncover crucial cellular targets that are affected by viral E6/E7 oncogene expression and that support the growth of HPV -positive cancer cells. Micro(mi) RNAs ...
E6 and E7 oncogenes ( 14–16 ). The E6 and E7 oncoproteins encoded by the high-risk HPVs bind and degrade the host p53 and retinoblastoma (pRb) tumor suppressor proteins, respectively ( 17 , 18 ...
]. Concerning our understanding about the role of the individual oncoproteins and their cross-talk with the host cell interactome, E6 and E7 either directly or indirectly interfere with innate immunosurveillance ...
oncoproteins . Given that HPV16 E7 causes increased KDM6A expression, we next determined whether HPV E7 oncoprotein expression was sufficient to generate KDM6A addiction. To test this hypothesis, we engineered ...
of these functions interferes with the HPV life cycle [13–16]. Despite our increased understanding of the HPV life cycle, there is still a clear need to understand how HPV and the host cell proteins it manipulates ...
the advent of the vaccines, accounting for more than 600,000 new cancer cases worldwide [2]. Indeed, even though cervical cancer is the most common cancer caused by HPV [3], a significant role of this virus ...
in these high-risk viral types (15). The mechanisms by which these high-risk viruses cause cancer are relatively well characterized. Particularly, the expression of HPV E6 and E7 viral proteins are essential ...
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