Access the full text.
Sign up today, get unlimited access with DeepDyve Pro!
points as classic reproductive toxicants. Selected Lesions of Dioxin in Rodents * Laboratory PETER MANN C. P.O. Box Laboratories , Inc., 12766, Experimental Pathology Research North Carolina 27709 Park ...
In a paper published in PLoS One and entitled ‘ Laboratory rodent diets contain toxic levels of environmental contaminants: Implications for regulatory tests’, Mesnage et al. (2015) analysed ...
and it is a multisite Park, NC 27709, USA carcinogen (1-3). In two-stage models of carcinogenesis, 'To whom correspondence should be addressed at: Laboratory of TCDD is a potent tumor promoter in rodent skin and liver (4 ...
tissue. In addition, one cannot investigate the effect of dioxins on biochemical mechanisms active in the disease process in rodents with surgically induced lesions since menstruation and endometriosis ...
., 1984), bone (Miettinen et al., 2005), and teeth (Kattainen et al., 2001; Miettinen et al., 2002) in laboratory animals. Dioxin -like chemicals are reported to affect also human teeth development. High ...
-response relationship in the range of doses relevant to human exposures, and these doses are well below those at which tumors have been elicited in laboratory rodents . In this article, we review ...
of nearly 400 women employed in a Hamburg, Germany pesticide plant in which they were exposed to dioxin , found a significant increase in breast-cancer mortality (32). Some rodent studies using prenatal dioxin ...
Abstract Polychlorinated biphenyls (PCBs) are ubiquitous environmental toxicants which act as liver tumor promoters in rodents and can be classified as either dioxin -like or non- dioxin (phenobarbital ...
specific findings from the NTP dioxin -TEF-evaluation studies, focuses on the incidences and morphologic aspects of oral lesions across these studies. In addition, we discuss the literature concerning DLC ...
is in keeping with findings from other laboratories . For example, in rodent liver, Tnf-α and Il-1β gene expression has been shown to be induced by dioxin (Fan et al., 1997). Moreover, inhibition of TNF-α activity ...
Access the full text.
Sign up today, get unlimited access with DeepDyve Pro!