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vascular smooth muscle contractility is regulated are not completely elucidated. Recent studies show that the actin cytoskeleton in smooth muscle is dynamic, which regulates force development. In this review ...
and in human diseases, mainly cancers. An emerging pattern suggests that BORG family members cancer‐promoting properties are related to their ability to regulate the cytoskeleton , with many impacting ...
, lengths, and architecture of actin filaments. In turn, Tmods can indirectly modulate the mechanical properties of the actin cytoskeleton and the physiological properties of cells. Tmod1 was first identified ...
of the actin cytoskeleton and its ability to be rapidly assembled and disassemblt�d must be harnessed. Since physiological conditions favor the spontaneous assembly of polymerized (F) actin from monomeric (G ...
and differences between these proteins, their role in the formation of physiological actin bundles, and their properties —both related and unrelated to their bundling abilities. We also review some aspects ...
Cell physiological processes require the regulation and coordination of both mechanical and dynamical properties of the actin cytoskeleton . Here we review recent advances in understanding ...
-associated kinase Rock1 is an upstream regulator that modulates key properties of the cytoplasmic cytoskeleton . Our research shows that Rock1 concentrations were reduced significantly in senescent cells ...
The local environment surrounding airway smooth muscle cells (ASM) has profound effects on the physiologic and phenotypic properties of ASM tissues. ASM is continually subjected to the mechanical ...
. These experiments reveal that the spectrin- actin membrane skeleton and beaded filament cytoskeleton establish a novel functional synergy critical for regulating lens fiber cell geometry, transparency, and mechanical ...
involved in regulation of the actin cytoskeleton , they possess some unique features. For instance, they are implicated in invasion by pathogenic bacteria such as Shigella flexneri and Salmonella typhimurium ...
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