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that the conjugation Inhibition of Tumor Metastasis a by Synthetic a Cell-Adhesive Polymer Containing RGDS Peptide HIROYUKI IKUO YU IGARASHI AND ICHIRO AZUMA KOMAZAWA, SAIKI,* Institute Science of Immunological Hokkaido ...
influenced by ficin and bromelain, as shown in an in vitro invasion system. Other experiments were performed with arg-gly-asp- containing synthetic peptides (RGD polymer ) as attachment protein mimicking ...
a potential use in inhibition of tumor metastasis , arteriosclerosis, and inflammation. © 2002 Wiley‐Liss, Inc. Abbreviations: SMCs, smooth muscle cells; HS, heparan sulfate; HSPGs, heparan sulfate ...
or polymers at the nanoscale to enhance penetration and accumulation of Hb in tumor tissues [46,47]. Nanomaterials containing human serum albumin and Hb (C@HOPC) were prepared via a protein hybridization ...
metastasis remain poorly understood. Metastasis , defined as the spread of malignant tumor cells from the primary tumor mass to distant sites, involves a complex series of interconnected events. Understanding ...
chemotherapy. Given the important role CICs play in tumor metastasis and dissemination [40], our results suggest that PARP inhibition with chemotherapy impairs the ability of CICs to drive CRC maintenance ...
effects on phosphorylation of ERK1/2. This study provides a framework for future studies to understand molecular targets of phytochemicals and evaluate their effectiveness in inhibiting metastasis in animal ...
D-PODO in tumor -bearing mice revealed a 50–60% inhibition of skin tumor formation. Histopathology and immunohistochemistry studies revealed that D-PODO treatment reduced epithelial hyperplasia ...
inhibition induces apoptosis and decreases proliferation of the cancerous cells (18). In contrast, overexpression of the same miRNA in neuroblastoma cell lines inhibits proliferation and reduces tumor growth ...
]. They also have the ability to inhibit the invasion and metastasis of tumor cells in vivo [43]. Treatment of noninvasive, nonmetastatic Swiss 3T3 cells with antisense TIMP-1 conferred oncogenicity ...
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