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Grey matter abnormalities in multiple sclerosis: proton magnetic resonance spectroscopic imaging

Multiple Sclerosis , Volume 7 (4) – Aug 1, 2001

Details

Publisher
Sage Publications
Copyright
\xA9 2001 by SAGE Publications
ISSN
1352-4585
eISSN
1477-0970
D.O.I.
10.1177/135245850100700402
Publisher site
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Grey matter abnormalities in multiple sclerosis: proton magnetic resonance spectroscopic imaging

Abstract

Pathologically defined abnormalities in the cortical gray matter (GM) are well described in multiple sclerosis (MS) but are infrequently seen by conventional magnetic resonance imaging (MRI). We systematically evaluated 52 relapsing - remitting MS patients and 20 normal volunteers with high resolution MRI and short echo proton magnetic resonance spectroscopic imaging (MRSI). Individual tissue contributions to the spectroscopic voxels were estimated based on MRI that incorporated both CSF suppression and magnetization transfer, or double inversion images in which both CSF and GM were suppressed. Strong resonances in the 0.8 to 1.5 p.p.m. spectral region were observed in 13 MS patients. Image segmentation based on the MRI characteristics of tissues contributing to the spectroscopic voxels showed that these additional peaks originated mainly from GM. The presence of these additional peaks suggests that the normal appearance GM on MRI, is biochemically abnormal in a substantial proportion of relapsing-remitting MS patients.
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