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Insufficiency : of Dysregulation Collagen Synthesis Alain Cecile Patricia PhD, Sansilvestri-Morel, PhD, PhD, Badier-Commander, Rupin, and J. Suresnes and France Jean-Noël Fabiani, MD,* Verbeuren, PhD, Paris ...
of posttranslational steps in the synthesis of both proteins by smooth muscle cells from varicose veins. IntroductionPrimary varicose veins are the most common manifestation of chronic venous insufficiency [1 ...
. These findings suggest a dysregulation of the synthesis of collagen I and III in smooth muscle cells derived from varicose veins. IntroductionVaricose veins are a common manifestation of chronic venous ...
, Rupin A, Jaisson S, Fabiani JN, Verbeuren TJ, Vanhoutte PM. Synthesis of collagen is dysregulated in cultured fibroblasts derived from skin of subjects with varicose veins as it is in venous smooth muscle ...
, Geneva, Switzerland), containing phenolic compounds extracted from the bark of a French maritime plant, may improve the symptoms of chronic venous insufficiency through its anti-inflammatory properties ...
% of the population are affected by chronic venous ulcers3 and, in the United States, it is estimated that approximately 500,000 to 600,000 people suffer venous ulcers, which increase in prevalence with age.4,5 ...
an important counterregulatory role, IL-10, like most cytokines, has injurious effects with excessive expression, including possibly causing the failed closure of chronic venous insufficiency ulcers.89 GROWTH ...
as current and future medical treatments that target ECM directly or indirectly. Uterine leiomyoma is characterized by elevated levels of collagens , fibronectin, laminins and proteoglycans. They can induce ...
as well as the dysregulated chronic inflammation characterizing IBD. Chronically inflamed IBD microvessels demonstrate an enhanced capacity to adhere leukocytes after inflammatory activation and have ...
in mice alone. The combination of hypoxia and sustained increases in endothelial cell proliferation, angiogenic growth factors, dysregulated erythropoiesis, and macrophage activation is proposed as the key ...
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