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metabolism in vascular and disease Arginine biology M Jr Sidney Morris, role in cardiovascular and Abstract: metabolism a Arginine plays major physiology It is via nitric oxide pathophysiology, largely ...
Arginine metabolism plays a major role in cardiovascular physiology and pathophysiology, largely via nitric oxide (NO)-dependent processes. It is becoming increasingly apparent, however ...
, leukotrienes and glutaminolysis are upregulated, and phospholipid-prostacyclin and L- arginine -nitric oxide pathway are compromised in lung vascular cells. Fatty acid metabolism is disordered in lung endothelial ...
led to the realisation that the L‐ arginine : NO pathway is widespread and plays a variety of physiological roles. These include the maintenance of vascular tone, neurotransmitter function in both ...
. In this Review, we focus on the regulation of NO via the synthesis and availability of its precursor, arginine , and discuss the implications of this metabolic regulation for cancer biology and therapy. Despite ...
. Specifically, the amino acids l- arginine (Arg), l-homoarginine (hArg) and l-tryptophan (Trp) have been widely studied in the context of cardiovascular disease , and their metabolism has been established as key ...
of oxidative stress in the nervous system and related organ systems in relation to aging, immune function, vascular biology , metabolism , cellular survival and cellular longevity. Oxidative stress impacts almost ...
in the nervous system and related organ systems in relation to aging, immune function, vascular biology , metabolism , cellular survival and cellular longevity. Oxidative stress impacts almost all acute and chronic ...
Nitric oxide (NO) generated from L- arginine by NO synthases in the endothelium and in other cells plays a central role in several aspects of vascular biology and has been linked to many regulatory ...
Type 2 Diabetes (T2D) is a metabolic disease associated with long-term complications, with a multifactorial pathogenesis related to the interplay between genetic and modifiable risk factors, of which ...
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